ArticleThe British journal of psychiatry : the journal of mental science2011
Polygenic dissection of the bipolar phenotype.
Article in The British journal of psychiatry : the journal of mental science, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.
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Who cites it
35 citing papers in PubMed, 1 synthesis or guideline pooled it, 74 citations in OpenAlex.
- Genome-wide association of mood-incongruent psychotic bipolar disorder.Translational psychiatry · 2012Pooled it
- Family study of bipolar disorder with comorbid anxiety disorder points toPCN reports : psychiatry and clinical neurosciences · 2025Article
- Genomic findings in schizophrenia and their implications.Molecular psychiatry · 2023Review
- Interactive effects of polygenic risk and cognitive subtype on brain morphology in schizophrenia spectrum and bipolar disorders.European archives of psychiatry and clinical neuroscience · 2022Article
- Pleiotropy between language impairment and broader behavioral disorders-an investigation of both common and rare genetic variants.Journal of neurodevelopmental disorders · 2021Article
- Analysis of genetic differences between psychiatric disorders: exploring pathways and cell types/tissues involved and ability to differentiate the disorders by polygenic scores.Translational psychiatry · 2021Article
- Epigenetic biotypes of post-traumatic stress disorder in war-zone exposed veteran and active duty males.Molecular psychiatry · 2021Article
- Developing and testing high-efficacy patient subgroups within a clinical trial using risk scores.Statistics in medicine · 2020Article
- Dissecting clinical heterogeneity of bipolar disorder using multiple polygenic risk scores.Translational psychiatry · 2020Article
- Polygenic risk for anxiety influences anxiety comorbidity and suicidal behavior in bipolar disorder.Translational psychiatry · 2020Article
- Schizophrenia Polygenic Risk and Brain Structural Changes in Methamphetamine-Associated Psychosis in a South African Population.Frontiers in genetics · 2020Article
- Polygenic risk scores in psychiatry: Will they be useful for clinicians?F1000Research · 2019Review
- Prediction of treatment response in rheumatoid arthritis patients using genome-wide SNP data.Genetic epidemiology · 2018Article
- Association of schizophrenia polygenic risk score with manic and depressive psychosis in bipolar disorder.Translational psychiatry · 2018Article
- Polygenic risk score: use in migraine research.The journal of headache and pain · 2018Review
- Association Between Schizophrenia-Related Polygenic Liability and the Occurrence and Level of Mood-Incongruent Psychotic Symptoms in Bipolar Disorder.JAMA psychiatry · 2018Article
- Comparison of weighting approaches for genetic risk scores in gene-environment interaction studies.BMC genetics · 2017Article
- Polygenic Epidemiology.Genetic epidemiology · 2016Review
- Inherited determinants of Crohn's disease and ulcerative colitis phenotypes: a genetic association study.Lancet (London, England) · 2016Article
- Assessment of first and second degree relatives of individuals with bipolar disorder shows increased genetic risk scores in both affected relatives and young At-Risk Individuals.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2015Article
Corrections and comments
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Authors and funding
21 authors at 10 institutions in 4 countries.
Funding
Abstract
backgroundRecent data provide strong support for a substantial common polygenic contribution (i.e. many alleles each of small effect) to genetic susceptibility for schizophrenia and overlapping susceptibility for bipolar disorder.
aimsTo test hypotheses about the relationship between schizophrenia and psychotic types of bipolar disorder.
methodUsing a polygenic score analysis to test whether schizophrenia polygenic risk alleles, en masse, significantly discriminate between individuals with bipolar disorder with and without psychotic features. The primary sample included 1829 participants with bipolar disorder and the replication sample comprised 506 people with bipolar disorder.
resultsThe subset of participants with Research Diagnostic Criteria schizoaffective bipolar disorder (n = 277) were significantly discriminated from the remaining participants with bipolar disorder (n = 1552) in both the primary (P = 0.00059) and the replication data-sets (P = 0.0070). In contrast, those with psychotic bipolar disorder as a whole were not significantly different from those with non-psychotic bipolar disorder in either data-set.
conclusionsGenetic susceptibility influences at least two major domains of psychopathological variation in the schizophrenia-bipolar disorder clinical spectrum: one that relates to expression of a 'bipolar disorder-like' phenotype and one that is associated with expression of 'schizophrenia-like' psychotic symptoms.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.