ArticleHuman molecular genetics2012
Methylation of L1Hs promoters is lower on the inactive X, has a tendency of being higher on autosomes in smaller genomes and shows inter-individual variability at some loci.
Article in Human molecular genetics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 31 citations in OpenAlex.
- Review
- Effects of DNA methylation on cardiometabolic risk factors: a systematic review and meta-analysis.Archives of public health = Archives belges de sante publique · 2022Review
- Analysis of epigenetic features characteristic of L1 loci expressed in human cells.Nucleic acids research · 2022Article
- Environmental and socio-cultural impacts on global DNA methylation in the indigenous Huichol population of Nayarit, Mexico.Environmental science and pollution research international · 2021Article
- Widespread DNA hypomethylation and differential gene expression in Turner syndrome.Scientific reports · 2016Article
- Retrotransposition creates sloping shores: a graded influence of hypomethylated CpG islands on flanking CpG sites.Genome research · 2015Article
- Genome-wide site-specific differential methylation in the blood of individuals with Klinefelter syndrome.Molecular reproduction and development · 2015Article
- Rapid reprogramming of epigenetic and transcriptional profiles in mammalian culture systems.Genome biology · 2015Article
- DNA methylation signature in peripheral blood reveals distinct characteristics of human X chromosome numerical aberrations.Clinical epigenetics · 2015Article
- Inter-locus as well as intra-locus heterogeneity in LINE-1 promoter methylation in common human cancers suggests selective demethylation pressure at specific CpGs.Clinical epigenetics · 2015Article
- Epigenomic and transcriptomic signatures of a Klinefelter syndrome (47,XXY) karyotype in the brain.Epigenetics · 2014Article
- Effects of age, sex, and persistent organic pollutants on DNA methylation in children.Environmental and molecular mutagenesis · 2014Article
- Plasma S-adenosylmethionine, DNMT polymorphisms, and peripheral blood LINE-1 methylation among healthy Chinese adults in Singapore.BMC cancer · 2013Article
- Autism genes keep turning up chromatin.OA autism · 2013Article
- Genetic and non-genetic predictors of LINE-1 methylation in leukocyte DNA.Environmental health perspectives · 2013Article
- LINE-1 methylation in visceral adipose tissue of severely obese individuals is associated with metabolic syndrome status and related phenotypes.Clinical epigenetics · 2012Article
- Long-lived epigenetic interactions between perinatal PBDE exposure and Mecp2308 mutation.Human molecular genetics · 2012Article
- Long interspersed nuclear element-1 hypomethylation and oxidative stress: correlation and bladder cancer diagnostic potential.PloS one · 2012Article
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Authors and funding
13 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
LINE-1 repeats account for ~17% of the human genome. Little is known about their individual methylation patterns, because their repetitive, almost identical sequences make them difficult to be individually targeted. Here, we used bisulfite conversion to study methylation at individual LINE-1 repeats. The loci studied included 39 X-linked loci and 5 autosomal loci. On the X chromosome in women, we found statistically significant less methylation at almost all L1Hs compared with men. Methylation at L1P and L1M did not correlate with the inactivation status of the host DNA, while the majority of L1Hs that were possible to be studied lie in inactivated regions. To investigate whether the male-female differences at L1Hs on the X are linked to the inactivation process itself rather than to a mere influence of gender, we analyzed six of the L1Hs loci on the X chromosome in Turners and Klinefelters which have female and male phenotype, respectively, but with reversed number of X chromosomes. We could confirm that all samples with two X chromosomes are hypomethylated at the L1Hs loci. Therefore, the inactive X is hypomethylated at L1Hs; the latter could play an exclusive role in the X chromosome inactivation process. At autosomal L1Hs, methylation levels showed a correlation tendency between methylation level and genome size, with higher methylation observed at most loci in individuals with one X chromosome and the lowest in XXY individuals. In summary, loci-specific LINE-1 methylation levels show considerable plasticity and depend on genomic position and constitution.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.