ArticleAutism research : official journal of the International Society for Autism Research2012
Pregnancy complications and obstetric suboptimality in association with autism spectrum disorders in children of the Nurses' Health Study II.
Article in Autism research : official journal of the International Society for Autism Research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 3 of them syntheses that pooled it.
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Who cites it
45 citing papers in PubMed, 3 syntheses or guidelines pooled it, 110 citations in OpenAlex.
- Association of Hypertensive Disorders of Pregnancy With Risk of Neurodevelopmental Disorders in Offspring: A Systematic Review and Meta-analysis.JAMA psychiatry · 2018Pooled it
- Association of maternal diabetes with autism spectrum disorders in offspring: A systemic review and meta-analysis.Medicine · 2018Pooled it
- Maternal diabetes and the risk of autism spectrum disorders in the offspring: a systematic review and meta-analysis.Journal of autism and developmental disorders · 2014Pooled it
- Risk Factors for Autism Spectrum Disorder in the Middle East and North Africa Region: A Systematic Review and Meta-Analysis of Confounder-Adjusted Studies.Journal of autism and developmental disorders · 2026Article
- The impact and mechanisms of preeclampsia on offspring neurodevelopment.Cell & bioscience · 2026Review
- Visualizing user demands through storyboarding in the mHealth app development for pregnant women: a conceptual framework.mHealth · 2025Review
- Inflammatory Conditions During Pregnancy and Risk of Autism and Other Neurodevelopmental Disorders.Biological psychiatry global open science · 2024Article
- Examining associations between prenatal biomarkers of oxidative stress and ASD-related outcomes using quantile regression.Journal of autism and developmental disorders · 2023Article
- Article
- Association between previous abortion history and risk of autism spectrum disorders among offspring: a meta-analysis.Clinical and experimental pediatrics · 2023Article
- Association of maternal polygenic risk scores for mental illness with perinatal risk factors for offspring mental illness.Science advances · 2022Article
- Cardiometabolic Pregnancy Complications in Association With Autism-Related Traits as Measured by the Social Responsiveness Scale in ECHO.American journal of epidemiology · 2022Article
- Pregnant Mothers' Medical Claims and Associated Risk of Their Children being Diagnosed with Autism Spectrum Disorder.Journal of personalized medicine · 2021Article
- Diabetes during Pregnancy: A Maternal Disease Complicating the Course of Pregnancy with Long-Term Deleterious Effects on the Offspring. A Clinical Review.International journal of molecular sciences · 2021Review
- Autism Spectrum Disorder from the Womb to Adulthood: Suggestions for a Paradigm Shift.Journal of personalized medicine · 2021Review
- Prevention in Autism Spectrum Disorder: A Lifelong Focused Approach.Brain sciences · 2021Review
- Gestational diabetes induces behavioral and brain gene transcription dysregulation in adult offspring.Translational psychiatry · 2020Article
- Foetal oestrogens and autism.Molecular psychiatry · 2020Article
- Relationship of prenatal maternal obesity and diabetes to offspring neurodevelopmental and psychiatric disorders: a narrative review.International journal of obesity (2005) · 2020Review
- Early alterations in a mouse model of Rett syndrome: the GABA developmental shift is abolished at birth.Scientific reports · 2019Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
The authors examined pregnancy and obstetric complications in association with autism spectrum disorders (ASD) in children of participants from the Nurses' Health Study II, a prospective national cohort with information collected through biennial mailed questionnaires since 1989. Logistic regression was used to obtain crude and adjusted odds ratios for ASD, and by diagnostic subgroup. Seven hundred and ninety-three cases were reported among 66,445 pregnancies. Pregnancy complications and obstetric suboptimality factors were assessed by maternal report of occurrence in first birth and, in secondary analyses, in any birth. Complications and a suboptimality score were significantly associated with having a child with ASD (OR 1.49, 95% CI 1.26, 1.77, P<0.0001 for pregnancy complications in first birth and 2.76, 95% CI 2.04, 3.74, P<0.0001 comparing individuals with four or more obstetric suboptimality factors in first birth to those with none; results similar when assessed in any birth). In particular, gestational diabetes was associated with a significantly increased risk of ASD in results of primary and sensitivity analyses (OR in primary analysis = 1.76, 95% CI 1.34, 2.32, P<0.0001); suboptimal parity and suboptimal age-at-first-birth were also individual factors associated with ASD. Associations were similar by diagnostic subgroup, suggesting autism, Asperger syndrome, and other Pervasive Developmental Disorders are all associated with pregnancy complications. Consistent with previous research, the general class of pregnancy complications was associated with ASD as a whole. Additional work will be required to more fully assess the role of gestational diabetes.
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