ArticleHernia : the journal of hernias and abdominal wall surgery2012
Three-year results from a preclinical implantation study of a long-term resorbable surgical mesh with time-dependent mechanical characteristics.
Article in Hernia : the journal of hernias and abdominal wall surgery, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
47 citing papers in PubMed, 2 syntheses or guidelines pooled it, 106 citations in OpenAlex.
- Biosynthetic meshes in contaminated fields: where are we now? A systematic review and meta-analysis in humans.Hernia : the journal of hernias and abdominal wall surgery · 2023Pooled it
- Polydioxanone implants: A systematic review on safety and performance in patients.Journal of biomaterials applications · 2020Pooled it
- First-year complications after immediate breast reconstruction with a biological and a synthetic mesh in the same patient: A randomized controlled study.Journal of surgical oncology · 2021Trial
- TEP With Long-Term Resorbable Mesh in Patients With Indirect Inguinal Hernia.JSLS : Journal of the Society of Laparoendoscopic SurgeonsTrial
- How do we evaluate the remodeling and regeneration of absorbable meshes? Multi-dimensional evaluation parameters from multi-species.Hernia : the journal of hernias and abdominal wall surgery · 2026Review
- Early Performance of a Multifilament Resorbable Synthetic Mesh in Aesthetic Breast Surgery: A 206 Patient Experience.Aesthetic surgery journal. Open forum · 2026Article
- A 3D Printed Poly(ε-caprolactone)-Collagen Hybrid Mesh (TissueDerm) for Breast Reconstruction after Mastectomy in a Pig Model.Tissue engineering and regenerative medicine · 2026Article
- Evaluation of a self-gripping slowly resorbable mesh for ventral hernia repair: in vitro degradation and in vivo biocompatibility in a rabbit model.Journal of materials science. Materials in medicine · 2025Article
- Early Outcomes Using TIGR Mesh in Direct-to-Implant Breast Reconstruction.Plastic and reconstructive surgery. Global open · 2025Article
- Evaluation of Electrospun Poly-4-Hydroxybutyrate as Biofunctional and Degradable Scaffold for Pelvic Organ Prolapse in a Vaginal Sheep Model.Macromolecular bioscience · 2025Article
- Use of TIGR Synthetic Reabsorable Mesh in Primary Breast Reconstruction.Plastic and reconstructive surgery. Global open · 2025Article
- Article
- Biodegradable suture development-based albumin composites for tissue engineering applications.Scientific reports · 2024Article
- Two-Year Preclinical Evaluation of Long-Term Absorbable Poly-4-hydroxybutyrate Scaffold for Surgical Correction of Pelvic Organ Prolapse.International urogynecology journal · 2024Article
- A novel self-gripping long-term resorbable mesh providing temporary support for open primary ventral and incisional hernia.Journal of materials science. Materials in medicine · 2023Article
- The Effects of Tissue Healing Factors in Wound Repair Involving Absorbable Meshes: A Narrative Review.Journal of clinical medicine · 2023Review
- Abdominal wall hernia repair: from prosthetic meshes to smart materials.Materials today. Bio · 2023Review
- Prospective, multicenter study of antimicrobial-coated, noncrosslinked, acellular porcine dermal matrix (XenMatrix™ AB Surgical Graft) for hernia repair in all centers for disease control and prevention wound classes: 24-month follow-up cohort.Annals of medicine and surgery (2012) · 2023Article
- Evaluation of the short-term host response and biomechanics of an absorbable poly-4-hydroxybutyrate scaffold in a sheep model following vaginal implantation.BJOG : an international journal of obstetrics and gynaecology · 2022Article
- The use of a novel synthetic resorbable scaffold (TIGR MatrixHernia : the journal of hernias and abdominal wall surgery · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe purpose of this study was to evaluate the biocompatibility, local tissue effects and performance of a synthetic long-term resorbable test mesh (TIGR(®) Matrix Surgical Mesh) compared to a non-resorbable polypropylene control mesh following implantation in a sheep model.
methodsFull-thickness abdominal wall defects were created in 14 sheep and subsequently repaired using test or control meshes. Sacrifices were made at 4, 9, 15, 24 and 36 months and results in terms of macroscopic observations, histology and collagen analysis are described for 4, 9, 15, 24 and 36 months.
resultsThe overall biocompatibility was good, and equivalent in the test and control meshes while the resorbable mesh was characterized by a collagen deposition more similar to native connective tissue and an increased thickness of the integrating tissue. The control polypropylene mesh provoked a typical chronic inflammation persistent over the 36-month study period. As the resorbable test mesh gradually degraded it was replaced by a newly formed collagen matrix with an increasing ratio of collagen type I/III, indicating a continuous remodeling of the collagen towards a strong connective tissue. After 36 months, the test mesh was fully resorbed and only microscopic implant residues could be found in the tissue.
conclusionsThis study suggests that the concept of a long-term resorbable mesh with time-dependent mechanical characteristics offers new possibilities for soft tissue repair and reinforcement.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.