ArticleGraefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie2012
Association of dilated retinal arteriolar caliber with early age-related macular degeneration: the Handan Eye Study.
Article in Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.
- Diabetes mellitus and risk of age-related macular degeneration: a systematic review and meta-analysis.PloS one · 2014Pooled it
- Correlation of retino-choroidal thickness and vascular metrics with drusen volume as a severity marker of age-related macular degeneration.Eye (London, England) · 2025Article
- The role of the retinal vasculature in age-related macular degeneration: a spotlight on OCTA.Eye (London, England) · 2024Review
- Effects of smoking on the retina of patients with dry age-related macular degeneration by optical coherence tomography angiography.BMC ophthalmology · 2022Article
- Relationship of Retinal Vessel Caliber with Age-Related Macular Degeneration.Journal of ophthalmology · 2022Article
- Retinal Vessel Functionality Is Linked With ARMS2 A69S and CFH Y402H Polymorphisms and Choroidal Status in AMD Patients.Investigative ophthalmology & visual science · 2021Article
- Vascular Changes in Intermediate Age-Related Macular Degeneration Quantified Using Optical Coherence Tomography Angiography.Translational vision science & technology · 2019Article
- Genome-wide association analyses identify 139 loci associated with macular thickness in the UK Biobank cohort.Human molecular genetics · 2019Article
- Agreement study between color and IR retinal images based on retinal vasculature morphological parameters.BMC ophthalmology · 2019Article
- Association of Retinal Vascular Caliber and Age-Related Macular Degeneration in Patients With the Acquired Immunodeficiency Syndrome.Investigative ophthalmology & visual science · 2018Article
- Inter-method agreement in retinal blood vessels diameter analysis between Dynamic Vessel Analyzer and optical coherence tomography.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2017Article
- Comparison of Common Retinal Vessel Caliber Measurement Software and a Conversion Algorithm.Translational vision science & technology · 2016Article
- Update on retinal vascular caliber.Romanian journal of ophthalmologyReview
- Comparison of subjective and objective methods to determine the retinal arterio-venous ratio using fundus photography.Journal of optometryArticle
Corrections and comments
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Authors and funding
8 authors at 6 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTo identify factors associated with early age-related macular degeneration (AMD) in a rural Chinese population, with emphasis on retinal vessel caliber.
methodsThe study population comprised the 6,830 participants of the Handan Eye Study. All participants underwent digital retinal photography of both eyes. Trained graders assessed the presence of AMD lesions. Arteriolar and venular diameters were measured with a specific computer-assisted program and were summarized as the central retinal arteriolar equivalent (CRAE) and central retinal venular equivalent (CRVE).
resultsThe data for the 199 individuals with evaluable retinal photographs and early AMD and 400 age-matched individuals randomly selected from the group without AMD were analyzed. After adjusting for participants' age, sex, smoking status, hypertension, diabetes, BMI, and CRVE, the multivariate adjusted model showed that a higher CRAE was significantly associated with early AMD (OR = 1.34; 95% CI: 1.05-1.71; p = 0.020) and the presence of soft distinct drusen (OR = 1.32 (95% CI: 1.02-1.71, p = 0.037). There were no significant associations between CRVE and early AMD.
conclusionsDilated retinal arteriolar caliber is associated with early AMD and soft distinct drusen in this population. We found no significant associations between CRAE and other characteristics of the retina related to AMD or between retinal venal caliber and early AMD. More research is needed to determine whether the difference between these results and those previously published stem from the rural living conditions of the participants or other factors.
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