Evidence map›Paper›PMID 21971720›Full record

ArticleClinical neuroradiology2012

Mechanical thrombectomy compared to local-intraarterial thrombolysis in carotid T and middle cerebral artery occlusions: a single center experience.

M Möhlenbruch, M Seifert, T Okulla, U Wüllner, D R Hadizadeh, M Nelles, S Greschus, K Wilhelm, H H Schild, T Klockgether and 1 more

Abstract readComparative StudyControlled Clinical Trial
PubMed Publisher
In one paragraph

Article in Clinical neuroradiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
5.2field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 37 citations in OpenAlex.

  1. Patient selection for mechanical thrombectomy.Clinical neuroradiology · 2014
    Trial
  2. Trial
  3. Article
  4. Review
  5. Article
  6. Mechanical thrombectomy using a combined CT/C-arm X-ray system.Journal of neurointerventional surgery · 2016
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Retrievable stent thrombectomy in the treatment of acute ischemic stroke: analysis of a revolutionizing treatment technique.Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia · 2013
    Review
  14. Article
  15. Article
  16. Treatment of acute ischemic stroke with clot retrieval devices.Current treatment options in cardiovascular medicine · 2012
    Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

M MöhlenbruchDepartments of Radiology/Neuroradiology, University of Bonn Medical Center, Sigmund Freud Str. 25, 53105 Bonn, Germany. markus.moehlenbruch@ukb.uni-bonn.de
M Seifert
T Okulla
U Wüllner
D R Hadizadeh
M Nelles
S Greschus
K Wilhelm
H H Schild
T Klockgether
H Urbach
University of Bonn · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe aim of the study was to examine the effects of mechanical thrombectomy using the Solitaire stent in patients with thromboembolic occlusions of the intracranial carotid artery bifurcation (carotid T) or middle cerebral artery (MCA) and to compare the results with a historical cohort treated with local intraarterial thrombolysis using urokinase.

methodsThe time intervals from stroke onset to treatment, recanalization rates, occlusion sites, recanalization times and functional outcomes on the modified Rankin scale at 3 months in 25 patients treated with the Solitaire stent between 2010 and 2011 were evaluated. The data were compared with those of a historical cohort of 62 patients treated with local intraarterial thrombolysis between 1992 and 2001.

resultsA total of 15 out of 25 (60%) patients treated with mechanical thrombectomy and 25 out of 62 (40%) treated with local intraarterial thrombolysis achieved a modified Rankin score of  ≤2 (p = 0.07). Occlusion sites, intervals from stroke onset to treatment and rates of parenchymal hematomas, 3 out of 25 (12%) versus 8 out of 62 (13%), were similar in both cohorts while the recanalization rate was significantly higher, 22 out of 25 (88%) versus 33 of 62 (53%), in the mechanical thrombectomy group (p ≤ 0.01).

conclusionThe data show that mechanical thrombectomy is superior to local intraarterial thrombolysis with respect to the recanalization rate in patients with thrombeoembolic carotid T or MCA occlusions.

Indexed as

AgedCarotid StenosisFibrinolytic AgentsHumansInfarction, Middle Cerebral ArteryInjections, Intra-ArterialMechanical ThrombolysisMiddle AgedRadiographyThrombolytic TherapyTreatment OutcomeUrokinase-Type Plasminogen ActivatorFibrinolytic AgentsUrokinase-Type Plasminogen Activator

Identifiers

PMID21971720
OpenAlexW164535898

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.