ArticleJournal of lipid research2011
Lipid body formation during maturation of human mast cells.
Article in Journal of lipid research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02498119 (The Role of Arachidonic Acid Metabolites, in the Lipid Droplets of Macrophages From Patients With Metabolic Syndrome), which is not on this map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Role of Arachidonic Acid Metabolites, in the Lipid Droplets of Macrophages From Patients With Metabolic Syndrome
Who cites it
22 citing papers in PubMed.
- Theory of Lipid Metabolism Disorders in Rhinitis and Asthma (Lipid Droplets).Cell biochemistry and biophysics · 2025Review
- Article
- Lipid droplets: a cellular organelle vital in cancer cells.Cell death discovery · 2023Review
- Lipid droplets and the host-pathogen dynamic: FATal attraction?The Journal of cell biology · 2021Review
- Hepatic lipid droplets: A balancing act between energy storage and metabolic dysfunction in NAFLD.Molecular metabolism · 2021Review
- Lipid Droplets and Their Autophagic Turnover via the Raft-Like Vacuolar Microdomains.International journal of molecular sciences · 2021Review
- Insulin-induced lipid body accumulation is accompanied by lipid remodelling in model mast cells.Adipocyte · 2019Article
- Lipid Droplets in Cancer: Guardians of Fat in a Stressful World.Molecules (Basel, Switzerland) · 2018Review
- Precise and economic FIB/SEM for CLEM: with 2 nm voxels through mitosis.Histochemistry and cell biology · 2018Article
- Lipid droplet functions beyond energy storage.Biochimica et biophysica acta. Molecular and cell biology of lipids · 2017Review
- Reduced expression of adipose triglyceride lipase decreases arachidonic acid release and prostacyclin secretion in human aortic endothelial cells.Archives of physiology and biochemistry · 2017Article
- Perilipins: a diversity of intracellular lipid droplet proteins.Lipids in health and disease · 2017Review
- Nanoimaging granule dynamics and subcellular structures in activated mast cells using soft X-ray tomography.Scientific reports · 2016Article
- Adipose triglyceride lipase acts on neutrophil lipid droplets to regulate substrate availability for lipid mediator synthesis.Journal of leukocyte biology · 2015Article
- Article
- Lipolysis meets inflammation: arachidonic acid mobilization from fat.Journal of lipid research · 2014Article
- Adipose triglyceride lipase regulates eicosanoid production in activated human mast cells.Journal of lipid research · 2014Article
- Lipid body accumulation alters calcium signaling dynamics in immune cells.Cell calcium · 2014Article
- Activated human mast cells induce LOX-1-specific scavenger receptor expression in human monocyte-derived macrophages.PloS one · 2014Article
- Autophagy facilitates antibody-enhanced dengue virus infection in human pre-basophil/mast cells.PloS one · 2014Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
Lipid droplets, also called lipid bodies (LB) in inflammatory cells, are important cytoplasmic organelles. However, little is known about the molecular characteristics and functions of LBs in human mast cells (MC). Here, we have analyzed the genesis and components of LBs during differentiation of human peripheral blood-derived CD34(+) progenitors into connective tissue-type MCs. In our serum-free culture system, the maturing MCs, derived from 18 different donors, invariably developed triacylglycerol (TG)-rich LBs. Not known heretofore, the MCs transcribe the genes for perilipins (PLIN)1-4, but not PLIN5, and PLIN2 and PLIN3 display different degrees of LB association. Upon MC activation and ensuing degranulation, the LBs were not cosecreted with the cytoplasmic secretory granules. Exogenous arachidonic acid (AA) enhanced LB genesis in Triacsin C-sensitive fashion, and it was found to be preferentially incorporated into the TGs of LBs. The large TG-associated pool of AA in LBs likely is a major precursor for eicosanoid production by MCs. In summary, we demonstrate that cultured human MCs derived from CD34(+) progenitors in peripheral blood provide a new tool to study regulatory mechanisms involving LB functions, with particular emphasis on AA metabolism, eicosanoid biosynthesis, and subsequent release of proinflammatory lipid mediators from these cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.