ReviewThe AAPS journal2011
Factors influencing the use and interpretation of animal models in the development of parenteral drug delivery systems.
Review in The AAPS journal, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The impact of phosphodiesterase inhibition on neurobehavioral outcomes in preclinical models of traumatic and non-traumatic spinal cord injury: a systematic review.Frontiers in medicine · 2023Pooled it
- Pharmacokinetics of Single-bolus Subcutaneous Cefovecin in C57BL/6 Mice.Journal of the American Association for Laboratory Animal Science : JAALAS · 2017Trial
- Physiologically Based Pharmacokinetic Modeling of Inhaled Polymyxin B: From Rabbit Optimization to Human Predictions.Pharmaceutical research · 2026Article
- A Review on Lymphatic Uptake of Large Therapeutic Proteins after Subcutaneous Injection.Pharmaceutical research · 2026Review
- Damage Associated Molecular Patterns (DAMPs) Mediate the Foreign Body Response to Poly(ethylene glycol) Diacrylate Hydrogels via Toll like Receptors.ACS biomaterials science & engineering · 2025Article
- The foreign body response to biomaterial implants is reduced by co-inhibition of TLR2 and TLR4.Acta biomaterialia · 2025Article
- Insights into interspecies protein binding variability using clindamycin as an example.The Journal of antimicrobial chemotherapy · 2025Article
- Acute toxicity effects of ethylene glycol on lethal dose 50 (LDOpen veterinary journal · 2024Article
- Interspecies variability in protein binding of antibiotics basis for translational PK/PD studies-a case study using cefazolin.Antimicrobial agents and chemotherapy · 2024Article
- Determination of osimertinib concentration in rat plasma and lung/brain tissues.American journal of translational research · 2024Article
- Imaging of large volume subcutaneous deposition using MRI: exploratory clinical study results.Drug delivery and translational research · 2023Article
- Interspecies and in vitro-in vivo scaling for quantitative modeling of whole-body drug pharmacokinetics in patients: Application to the anticancer drug oxaliplatin.CPT: pharmacometrics & systems pharmacology · 2023Article
- Childhood Brain Tumors: A Review of Strategies to Translate CNS Drug Delivery to Clinical Trials.Cancers · 2023Review
- Protein Binding in Translational Antimicrobial Development-Focus on Interspecies Differences.Antibiotics (Basel, Switzerland) · 2022Review
- Specificity of plasma oxytocin immunoassays: A comparison of commercial assays and sample preparation techniques using oxytocin knockout and wildtype mice.Psychoneuroendocrinology · 2021Article
- Nonsteroidal Anti-Inflammatory Drugs and Their Neuroprotective Role After an Acute Spinal Cord Injury: A Systematic Review of Animal Models.Global spine journal · 2021Article
- Deschloroclozapine, a potent and selective chemogenetic actuator enables rapid neuronal and behavioral modulations in mice and monkeys.Nature neuroscience · 2020Article
- Autologous plasma versus fetal calf serum as a supplement for the culture of neutrophils.BMC research notes · 2020Article
- Advanced drug delivery 2020 and beyond: Perspectives on the future.Advanced drug delivery reviews · 2020Review
- Disease-directed engineering for physiology-driven treatment interventions in neurological disorders.APL bioengineering · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Depending upon the drug and drug delivery platform, species-specific physiological differences can lead to errors in the interspecies extrapolation of drug performance. This manuscript provides an overview of the species-specific physiological variables that can influence the performance of parenteral dosage forms such as in situ forming delivery systems, nanoparticles, microspheres, liposomes, targeted delivery systems, lipophilic solutions, and aqueous suspensions. Also discussed are those factors that can influence the partitioning of therapeutic compounds into tumors, the central nervous system and the lymphatics. Understanding interspecies differences in the movement and absorption of molecules is important to the interpretation of data generated through the use of animal models when studying parenteral drug delivery.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.