ArticleJournal of neuroscience research2012
Postnatal morphine administration alters hippocampal development in rats.
Article in Journal of neuroscience research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 39 citations in OpenAlex.
- Morphine exposure and prematurity affect flash visual evoked potentials in preterm infants.Clinical neurophysiology practice · 2024Article
- Body size and brain volumetry in the rat following prolonged morphine administration in infancy and adulthood.Frontiers in pain research (Lausanne, Switzerland) · 2023Article
- GABA and glutamate in the preterm neonatal brain: In-vivo measurement by magnetic resonance spectroscopy.NeuroImage · 2021Review
- Long-term behavioral effects observed in mice chronically exposed to static ultra-high magnetic fields.Magnetic resonance in medicine · 2021Article
- Identifying the Neurodevelopmental Differences of Opioid Withdrawal.Cellular and molecular neurobiology · 2021Article
- Indices of dentate gyrus neurogenesis are unaffected immediately after or following withdrawal from morphine self-administration compared to saline self-administering control male rats.Behavioural brain research · 2020Article
- Exposure to Morphine and Caffeine Induces Apoptosis and Mitochondrial Dysfunction in a Neonatal Rat Brain.Frontiers in pediatrics · 2020Article
- Dentate gyrus μ-opioid receptor-mediated neurogenic processes are associated with alterations in morphine self-administration.Scientific reports · 2019Article
- Normal glutathione levels in autopsied brain of chronic users of heroin and of cocaine.Drug and alcohol dependence · 2018Article
- Opiate Drugs with Abuse Liability Hijack the Endogenous Opioid System to Disrupt Neuronal and Glial Maturation in the Central Nervous System.Frontiers in pediatrics · 2017Review
- Fentanyl and Midazolam Are Ineffective in Reducing Episodic Intracranial Hypertension in Severe Pediatric Traumatic Brain Injury.Critical care medicine · 2016Article
- Honokiol for the Treatment of Neonatal Pain and Prevention of Consequent Neurobehavioral Disorders.Journal of natural products · 2015Article
- The neurochemical profile of the hippocampus in isoflurane-treated and unanesthetized rat pups.Interdisciplinary toxicology · 2015Article
- Proteomic analysis of post-nuclear supernatant fraction and percoll-purified membranes prepared from brain cortex of rats exposed to increasing doses of morphine.Proteome science · 2014Article
- Crosstalk between delta opioid receptor and nerve growth factor signaling modulates neuroprotection and differentiation in rodent cell models.International journal of molecular sciences · 2013Article
- Opioid receptors: distinct roles in mood disorders.Trends in neurosciences · 2013Review
- Adult responses to an ischemic stroke in a rat model of neonatal stress and morphine treatment.International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience · 2013Article
- Long-term effects of neonatal stress on adult conditioned place preference (CPP) and hippocampal neurogenesis.Behavioural brain research · 2012Article
- Endogenous and exogenous opioid effects on oligodendrocyte biology and developmental brain myelination.Neurotoxicology and teratologyReview
- Reducing Opioid Exposure in a Level IV Neonatal Intensive Care Unit.Pediatric quality & safetyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Morphine is frequently used as an analgesic and sedative in preterm infants. Adult rats exposed to morphine have an altered hippocampal neurochemical profile and decreased neurogenesis in the dentate gyrus of the hippocampus. To evaluate whether neonatal rats are similarly affected, rat pups were injected twice daily with 2 mg/kg morphine or normal saline from postnatal days 3 to 7. On postnatal day 8, the hippocampal neurochemical profile was determined using in vivo (1)H NMR spectroscopy. The mRNA and protein concentrations of specific analytes were measured in hippocampus, and cell division in dentate gyrus was assessed using bromodeoxyuridine. The concentrations of γ-aminobutyric acid (GABA), taurine, and myo-insotol were decreased, whereas concentrations of glutathione, phosphoethanolamine, and choline-containing compounds were increased in morphine-exposed rats relative to control rats. Morphine decreased glutamic acid decarboxylase enzyme levels and myelin basic protein mRNA expression in the hippocampus. Bromodeoxyuridine labeling in the dentate gyrus was decreased by 60-70% in morphine-exposed rats. These results suggest that recurrent morphine administration during brain development alters hippocampal structure.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.