ArticleNature communications2011
Reprogramming within hours following nuclear transfer into mouse but not human zygotes.
Article in Nature communications, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
33 citing papers in PubMed.
- A large retrospective study on 1PN embryo transfer supports the need for updated harmonized best practice guidelines.Human reproduction (Oxford, England) · 2026Article
- Cloning by SCNT: Integrating Technical and Biology-Driven Advances.Methods in molecular biology (Clifton, N.J.) · 2023Article
- Article
- HIRA contributes to zygote formation in mice and is implicated in human 1PN zygote phenotype.Reproduction (Cambridge, England) · 2021Article
- Lessons Learned from Somatic Cell Nuclear Transfer.International journal of molecular sciences · 2020Review
- Various nuclear reprogramming systems using egg and oocyte materials.The Journal of reproduction and development · 2019Review
- Somatic Cell Nuclear Transfer Reprogramming: Mechanisms and Applications.Cell stem cell · 2018Review
- Inter-homologue repair in fertilized human eggs?Nature · 2018Article
- Widespread Mitotic Bookmarking by Histone Marks and Transcription Factors in Pluripotent Stem Cells.Cell reports · 2017Article
- Personhood status of the human zygote, embryo, fetus.The Linacre quarterly · 2017Article
- Genomic Instability of iPSCs: Challenges Towards Their Clinical Applications.Stem cell reviews and reports · 2017Review
- H1foo Has a Pivotal Role in Qualifying Induced Pluripotent Stem Cells.Stem cell reports · 2016Article
- Attitudes toward prevention of mtDNA-related diseases through oocyte mitochondrial replacement therapy.Human reproduction (Oxford, England) · 2016Article
- Ethical aspects of nuclear and mitochondrial DNA transfer.The Linacre quarterly · 2016Article
- Targeted Disruption of the β2-Microglobulin Gene Minimizes the Immunogenicity of Human Embryonic Stem Cells.Stem cells translational medicine · 2015Article
- Imbalance between the expression dosages of X-chromosome and autosomal genes in mammalian oocytes.Scientific reports · 2015Article
- Nuclear Reprogramming and Mitosis--how does mitosis enhance changes in gene expression?Transcription · 2015Article
- Human oocytes reprogram adult somatic nuclei of a type 1 diabetic to diploid pluripotent stem cells.Nature · 2014Article
- Article
- Mouse SCNT ESCs have lower somatic mutation load than syngeneic iPSCs.Stem cell reports · 2014Article
Corrections and comments
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Authors and funding
14 authors.
Funding
Abstract
Fertilized mouse zygotes can reprogram somatic cells to a pluripotent state. Human zygotes might therefore be useful for producing patient-derived pluripotent stem cells. However, logistical, legal and social considerations have limited the availability of human eggs for research. Here we show that a significant number of normal fertilized eggs (zygotes) can be obtained for reprogramming studies. Using these zygotes, we found that when the zygotic genome was replaced with that of a somatic cell, development progressed normally throughout the cleavage stages, but then arrested before the morula stage. This arrest was associated with a failure to activate transcription in the transferred somatic genome. In contrast to human zygotes, mouse zygotes reprogrammed the somatic cell genome to a pluripotent state within hours after transfer. Our results suggest that there may be a previously unappreciated barrier to successful human nuclear transfer, and that future studies could focus on the requirements for genome activation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.