Evidence map›Paper›PMID 21971474›Full record

Trial reportJournal of Alzheimer's disease : JAD2011

Cognitive training changes hippocampal function in mild cognitive impairment: a pilot study.

Allyson C Rosen, Lisa Sugiura, Joel H Kramer, Susan Whitfield-Gabrieli, John D Gabrieli

2 registry-linked trialsAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of Alzheimer's disease : JAD, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 86 papers, 16 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
86citing papers in PubMed, 16 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02920632 nacompletednot on this mapstarted 2017, after this paper: background citation

COGTIPS (COGnitive Training In Parkinson Study): The Effect of Online Cognitive Training on Cognition and Brain Networks in Parkinson's Disease

TypeinterventionalSponsorAmsterdam UMC, location VUmcRan2017 to 2021Enrolled167ConditionsParkinson Disease, Impaired Cognition, Alteration in CognitionArmsOnline cognitive training 1, Online cognitive training 2
NCT06656637 naenrolling by invitationnot on this mapstarted 2024, after this paper: background citation

To Drill or Not to Drill: Do Memory Drills Help Strengthen Prospective Memory and Decrease Veterans' Concerns About Prospective Memory Problems?

TypeinterventionalSponsorUniversity of California, Los AngelesRan2024 to 2026Enrolled75ConditionsMemory DeficitArmsMemory Drilling, Compensatory Strategies, Cognitive Processing Therapy
3 · Its place in the literature

Who cites it

86 citing papers in PubMed, 16 syntheses or guidelines pooled it.

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26 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Allyson C RosenDepartment of Psychiatry, Stanford University, Stanford, CA, USA. rosena@psych.stanford.edu
Lisa Sugiura
Joel H Kramer
Susan Whitfield-Gabrieli
John D Gabrieli

Funding

PrPSc SPECIFIC INTERACTION WITH NOVEL PrP-Fc FUSION PROTEINSP50AG023501 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MILLER, BRUCE L · 2004 to 2018
$27.1M
X-RAY COMPATIBLE RF-COIL FOR MR IMAGINGP41RR009784 · NCRR · STANFORD UNIVERSITY · PI GLOVER, GARY H · 1995 to 2011
$15.0M
Tau Truncation & Conformation In Alzheimer's Disease ProgressionP01AG009466 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI BINDER, LESTER IRVIN · 1991 to 2012
$14.3M
Mechanism of mitotic exit in budding yeastR01GM059940 · NIGMS · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI DESHAIES, RAYMOND J · 1999 to 2009
$1.7M
FMRI ANALYSIS OF DECLARATIVE MEMORYR01MH059940 · NIMH · STANFORD UNIVERSITY · PI GABRIELI, JOHN · 2000 to 2004
$1.6M
MEMORY AND MENTAL HEALTH IN AGINGR01MH035182 · NIMH · STANFORD UNIVERSITY · PI YESAVAGE, JEROME A · 1985 to 2005
$1.6M
FUNCTIONAL MRI ANALYSIS OF MEMORY IN AGING AND AMNESIAR01AG012995 · NIA · STANFORD UNIVERSITY · PI GABRIELI, JOHN · 1995 to 2001
$658k
FMRI and TMS Analysis of Frontal Lobes in AgingK01AG025157 · NIA · STANFORD UNIVERSITY · PI ROSEN, ALLYSON C · 2005 to 2009
$637k
AGING AND INHIBITORY BEHAVIOR: AN FMRI STUDYF32AG005865 · NIA · STANFORD UNIVERSITY · PI ROSEN, ALLYSON C · 1999 to 2002
$102k
MEMORY AND MENTAL HEALTH IN AGINGR37MH035182 · NIMH · STANFORD UNIVERSITY · PI YESAVAGE, JEROME A · 1990 to 1999
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NCRR NIH HHS P41 RR009784NCRR NIH HHS RR09784NIA NIH HHS AG05865 01NIA NIH HHS AG09466NIA NIH HHS AG12995NIA NIH HHS F32 AG005865NIA NIH HHS K01 AG025157NIA NIH HHS K01AG025157NIA NIH HHS P01 AG009466NIA NIH HHS P50 AG023501NIGMS NIH HHS R01 GM059940NIMH NIH HHS MH35182NIMH NIH HHS MH59940NIMH NIH HHS R01 MH035182NIMH NIH HHS R01 MH059940NIMH NIH HHS R37 MH035182
6 · The paper itself

Abstract

A randomized pilot experiment examined the neural substrates of response to cognitive training in participants with mild cognitive impairment (MCI). Participants performed exercises previously demonstrated to improve verbal memory and an active control group performed other computer activities. An auditory-verbal fMRI task was conducted before and after the two-month training program. Verbal memory scores improved significantly and left hippocampal activation increased significantly in the experimental group (gains in 5 of 6 participants) relative to the control group (reductions in all 6 participants). Results suggest that the hippocampus in MCI may retain sufficient neuroplasticity to benefit from cognitive training.

Indexed as

AgedAged, 80 and overBrain MappingCognitive Behavioral TherapyCognitive DysfunctionFemaleFollow-Up StudiesHippocampusHumansImage Processing, Computer-AssistedMagnetic Resonance ImagingMaleMiddle AgedNeuropsychological TestsOxygenPilot ProjectsOxygen

Identifiers

PMID21971474
PMCPMC3277842

What OpenQuestion holds

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LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.