Trial reportJournal of Alzheimer's disease : JAD2012
High-intensity physical activity modulates diet effects on cerebrospinal amyloid-β levels in normal aging and mild cognitive impairment.
Trial report in Journal of Alzheimer's disease : JAD, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it, 53 citations in OpenAlex.
- Physical activity and amyloid beta in middle-aged and older adults: A systematic review and meta-analysis.Journal of sport and health science · 2024Pooled it
- Effects of exercise versus usual care on older adults with amnestic mild cognitive impairment: EXERT versus ADNI.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Trial
- Comparative effectiveness of rhythmic grip training of various intensities on cognitive function in young adults: a fNIRS study.Frontiers in neuroscience · 2025Trial
- Evaluation of exploratory fluid biomarkers from a phase 1 senolytic trial in mild Alzheimer's disease.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2025Article
- Amyloid-beta metabolism in age-related neurocardiovascular diseases.European heart journal · 2025Review
- Research Progress and Trends in Exercise Interventions for Mild Cognitive Impairment: A Bibliometric Visualization Analysis Using CiteSpace.Journal of multidisciplinary healthcare · 2025Review
- High-intensity training on CREB activation for improving brain health: a narrative review of possible molecular talks.Frontiers in endocrinology · 2024Review
- Modifiable dementia risk factors and AT(N) biomarkers: findings from the EPAD cohort.Frontiers in aging neuroscience · 2024Article
- How does apolipoprotein E genotype influence the relationship between physical activity and Alzheimer's disease risk? A novel integrative model.Alzheimer's research & therapy · 2023Review
- Chinese nutraceuticals and physical activity; their role in neurodegenerative tauopathies.Chinese medicine · 2021Review
- Mechanistic Effects of Aerobic Exercise in Alzheimer's Disease: Imaging Findings From the Pilot FIT-AD Trial.Frontiers in aging neuroscience · 2021Article
- Centenarians, Supercentenarians: We Must Develop New Measurements Suitable for Our Oldest Old.Frontiers in psychology · 2021Article
- Effects of physical activities on dementia-related biomarkers: A systematic review of randomized controlled trials.Alzheimer's & dementia (New York, N. Y.) · 2020Review
- Dementia prevention and reserve against neurodegenerative disease.Dialogues in clinical neuroscience · 2019Article
- Article
- Effects of running on adiponectin, insulin and cytokines in cerebrospinal fluid in healthy young individuals.Scientific reports · 2019Article
- Moderate- to high-intensity exercise does not modify cortical β-amyloid in Alzheimer's disease.Alzheimer's & dementia (New York, N. Y.) · 2019Article
- Dietary patterns and β-amyloid deposition in aging Australian women.Alzheimer's & dementia (New York, N. Y.) · 2018Article
- Moderate intensity physical activity associates with CSF biomarkers in a cohort at risk for Alzheimer's disease.Alzheimer's & dementia (Amsterdam, Netherlands) · 2018Article
- Neuroplasticity and Clinical Practice: Building Brain Power for Health.Frontiers in psychology · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 5 institutions in 1 country.
Funding
Abstract
We previously showed that amyloid-β 1-42 (Aβ(42)) levels in cerebrospinal fluid (CSF) were markedly altered in response to a 4-week dietary intervention in normal aging and mild cognitive impairment (MCI). Here, we re-examined the data to assess whether diet-induced effects on CSF Aβ(42) were modulated by high intensity physical activity (hi-PA). Normal older adults (n = 18, mean age = 68.6 ± 7.4 y) and adults with amnestic MCI (n = 23, mean age = 68.0 ± 6.5 y) received a low saturated fat/low glycemic index (LOW) diet or a high saturated fat/high glycemic index (HIGH) diet, and CSF levels of Aβ(42), tau, and IL-8 were measured at baseline and week 4. Pre-study activity levels were assessed using a 7-d questionnaire, and weekly duration of hi-PA was quantified. At baseline, increased hi-PA in normals predicted lower CSF levels of tau (r = -0.54, p = 0.020) and IL-8 (r = -0.70, p = 0.025). Diet-induced effects on CSF Aβ(42) during the intervention study were modulated by hi-PA, and the nature of this effect differed for normals and MCI (ANOVA, p = 0.039). That is, for normal adults, increased hi-PA attenuated the effects of the HIGH diet on CSF Aβ(42) whereas in MCI, increased hi-PA potentiated the effects of the LOW diet. Our results suggest that normal adults who engage in hi-PA are less vulnerable to the pathological effects of an unhealthy diet, while in MCI, the benefit of a healthy diet on Aβ modulation is greatest when paired with hi-PA. Exercise may thus interact with diet to alter pathological processes that ultimately modify risk of Alzheimer's disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.