ArticleMutation research2012
In vitro genotoxicity testing strategy for nanomaterials and the adaptation of current OECD guidelines.
Article in Mutation research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
64 citing papers in PubMed, 231 citations in OpenAlex.
- Optimization of Cytokinesis-Block Micronucleus Assay for Clastogenic Risk Assessment of Silver-Containing Nanomaterials.Nanomaterials (Basel, Switzerland) · 2026Article
- Nanotoxicology: Emerging Challenges and Future Solutions for Safe Nanomaterial Applications.Nanomaterials (Basel, Switzerland) · 2026Review
- The Comet Assay in Nano-ecogenotoxicology.Methods in molecular biology (Clifton, N.J.) · 2026Article
- Tungsten carbide-cobalt can function as a particle positive control for genotoxicity in vitro in specific cell lines.Mutagenesis · 2025Article
- 25 years of research and regulation: Is nanotechnology safe to commercialize?Frontiers in toxicology · 2025Review
- Adapting the in vitro micronucleus assay (OECD Test Guideline No. 487) for testing of manufactured nanomaterials: recommendations for best practices.Mutagenesis · 2024Article
- Current status and future challenges of genotoxicity OECD Test Guidelines for nanomaterials: a workshop report.Mutagenesis · 2023Article
- Evaluation of Antioxidant Activity, Cytotoxicity, and Genotoxicity ofLife (Basel, Switzerland) · 2023Article
- The State of the Art and Challenges of In Vitro Methods for Human Hazard Assessment of Nanomaterials in the Context of Safe-by-Design.Nanomaterials (Basel, Switzerland) · 2023Review
- Genotoxicity and Toxicity Assessment of a Formulation Containing Silver Nanoparticles and Kaolin: An In Vivo Integrative Approach.Nanomaterials (Basel, Switzerland) · 2022Article
- Optimized High-Content Imaging Screening Quantifying Micronuclei Formation in Polymer-Treated HaCaT Keratinocytes.Nanomaterials (Basel, Switzerland) · 2022Article
- Toxicological Assessment of Cellulose Nanomaterials: Oral Exposure.Nanomaterials (Basel, Switzerland) · 2022Review
- Evaluating nanobiomaterial-induced DNA strand breaks using the alkaline comet assay.Drug delivery and translational research · 2022Article
- Nanosafety: An Evolving Concept to Bring the Safest Possible Nanomaterials to Society and Environment.Nanomaterials (Basel, Switzerland) · 2022Review
- Genotoxicity of Graphene-Based Materials.Nanomaterials (Basel, Switzerland) · 2022Review
- The application of existing genotoxicity methodologies for grouping of nanomaterials: towards an integrated approach to testing and assessment.Particle and fibre toxicology · 2022Article
- Development of reconstructed intestinal micronucleus cytome (RICyt) assay in 3D human gut model for genotoxicity assessment of orally ingested substances.Archives of toxicology · 2022Article
- In Vitro Genotoxicity Evaluation of an Antiseptic Formulation Containing Kaolin and Silver Nanoparticles.Nanomaterials (Basel, Switzerland) · 2022Article
- Improving Antibacterial Activity of a HtrA Protease Inhibitor JO146 againstPharmaceutics · 2022Article
- Particle Safety Assessment in Additive Manufacturing: From Exposure Risks to Advanced Toxicology Testing.Frontiers in toxicology · 2022Review
4 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
There is a pressing requirement to define a hazard identification and risk management strategy for nanomaterials due to the rapid growth in the nanotechnology industry and their promise of life-style revolutions through the development of wide-ranging nano-containing consumer products. Consequently, a battery of well defined and appropriate in vitro assays to assess a number of genotoxicity endpoints is required to minimise extensive and costly in vivo testing. However, the validity of the established protocols in current OECD recognised genotoxicity assays for nanomaterials is currently being questioned. In this report, we therefore consider the in vitro OECD genotoxicity test battery including the Ames, micronucleus and HPRT forward mutation assays, and their potential role in the safety assessment of nanomaterial induced DNA damage in vitro.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.