ArticleEuropean journal of clinical nutrition2012
Vitamin D and K status influences bone mineral density and bone accrual in children and adolescents with celiac disease.
Article in European journal of clinical nutrition, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 4 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 4 syntheses or guidelines pooled it, 75 citations in OpenAlex.
- Pooled it
- Short- and Long-Term Nutritional Status in Children and Adolescents with Celiac Disease Following a Gluten-Free Diet: A Systematic Review.Nutrients · 2025Pooled it
- Relationship between vitamin D levels and pediatric celiac disease: a systematic review and meta-analysis.BMC pediatrics · 2024Pooled it
- Nutritional Deficiencies in Children with Celiac Disease Resulting from a Gluten-Free Diet: A Systematic Review.Nutrients · 2019Pooled it
- Formula Milk Supplementation and Bone Acquisition in 4-6 Years Chinese Children: A 12-Month Cluster-Randomized Controlled Trial.Nutrients · 2023Trial
- Gluten-Free Diet: Nutritional Strategies to Improve Eating Habits in Children with Celiac Disease: A Prospective, Single-arm Intervention Study.Nutrients · 2021Trial
- Trial
- Restless legs syndrome in children with celiac disease: associations with vitamin D and iron deficiency and the role of gluten-free diet adherence.BMC pediatrics · 2026Article
- Challenges in the Pediatric Celiac Disease Diagnosis: An Up-to-Date Review.Diagnostics (Basel, Switzerland) · 2025Review
- Vitamin and trace elements imbalance are very common in adult patients with newly diagnosed Celiac disease.Scientific reports · 2025Article
- The Crosstalk between Vitamin D and Pediatric Digestive Disorders.Diagnostics (Basel, Switzerland) · 2022Review
- Effects of vitamin D on bone density in healthy children: A systematic review.Journal of family medicine and primary care · 2022Review
- Follow-up practices for children and adolescents with celiac disease: results of an international survey.European journal of pediatrics · 2022Article
- Narrative Review: Nutrient Deficiencies in Adults and Children with Treated and Untreated Celiac Disease.Nutrients · 2020Review
- Linear growth of children with celiac disease after the first two years on gluten- free diet: a controlled study.Acta bio-medica : Atenei Parmensis · 2019Article
- Micronutrients Dietary Supplementation Advices for Celiac Patients on Long-Term Gluten-Free Diet with Good Compliance: A Review.Medicina (Kaunas, Lithuania) · 2019Review
- Prevalence of and Risk Factors for Low Bone Mineral Density in Children With Celiac Disease.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2019Article
- Gluten-Free Diet: Gaps and Needs for a Healthier Diet.Nutrients · 2019Review
- Fat soluble vitamin levels in children with newly diagnosed celiac disease, a case control study.BMC pediatrics · 2018Article
- Bone mineral density and vitamin K status in children with celiac disease: Is there a relation?The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2018Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND/
objectivesChildren with celiac disease (CD) are at risk for decreased bone mineral density (BMD) because of fat-soluble vitamin malabsorption, inflammation and/or under-nutrition. The study objective was to determine the interrelationships between vitamin K/D status and lifestyle variables on BMD in children and adolescents with CD at diagnosis and after 1 year on the gluten-free diet (GFD). SUBJECTS/
methodsChildren and adolescents aged 3-17 years with biopsy proven CD at diagnosis and after 1 year on the GFD were studied. BMD was measured using dual-energy X-ray absorptiometry. Relevant variables included: anthropometrics, vitamin D/K status, diet, physical activity and sunlight exposure.
resultsWhole-body and lumbar-spine BMD-z scores were low (< or = -1) at diagnosis (10-20%) and after 1 year (30-32%) in the children, independent of symptoms. Whole-body BMD-z scores (-0.55±0.7 versus 0.72±1.5) and serum levels of 25(OH) vitamin D (90.3±24.8 versus 70.5±19.8 nmol/l) were significantly lower in older children (>10 years) when compared with younger children (< or =10 years) (P<0.001). Forty-three percent had suboptimal vitamin D status (25(OH)-vitamin D <75 nmol/l) at diagnosis; resolving in nearly half after 1 year on the GFD. Twenty-five percent had suboptimal vitamin K status at diagnosis; all resolved after 1 year.
conclusionsChildren and adolescents with CD are at risk for suboptimal bone health at time of diagnosis and after 1 year on GFD; likely due in part to suboptimal vitamin D/K status. Therapeutic strategies aimed at optimizing vitamin K/D intake may contribute to improved BMD in children with CD.
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