ArticleBritish journal of cancer2011
Risk factors for short- and long-term complications after groin surgery in vulvar cancer.
Article in British journal of cancer, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 3 of them syntheses that pooled it.
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Who cites it
43 citing papers in PubMed, 3 syntheses or guidelines pooled it, 117 citations in OpenAlex.
- Risk factors associated with postoperative lymphocele in patients with gynecological malignant tumors: a systematic review and meta-analysis.Frontiers in oncology · 2026Pooled it
- Incidence of lower limb lymphedema after vulvar cancer: A systematic review and meta-analysis.Medicine · 2017Pooled it
- Feasibility and Safety of Video Endoscopic Inguinal Lymphadenectomy in Vulvar Cancer: A Systematic Review.PloS one · 2015Pooled it
- Feasibility of a Pilot Randomized Controlled Trial Examining a Multidimensional Intervention in Women with Gynecological Cancer at Risk of Lymphedema.Current oncology (Toronto, Ont.) · 2021Trial
- Long-Term Outcomes, Morbidity and Quality of Life in Node-Negative Early-Stage Vulvar Cancer: Sentinel Node Biopsy versus Inguinofemoral Lymphadenectomy.Geburtshilfe und Frauenheilkunde · 2026Article
- Treatment patterns and outcomes in perineal primary vulvar cancer-a population-based Swedish cohort study.Acta obstetricia et gynecologica Scandinavica · 2026Article
- Depth of Invasion of 13 mm or Greater Accurately Predicted the Risk of Having a Node Positivity in Lymphadenectomy for Squamous Vulvar Cancer.The journal of obstetrics and gynaecology research · 2026Article
- The impact of local symptoms on health-related quality of life in vulvar cancer survivors-A nationwide prospective study.Acta obstetricia et gynecologica Scandinavica · 2025Observational
- The effect of intrawound vancomycin powder on surgical site infection in inguinal lymph node dissection: a randomized controlled trial pilot study.Gynecologic oncology reports · 2025Article
- Sentinel Lymphonodectomy in Early Vulvar Cancer in Daily Practice: a Multicenter Experience from Germany.Geburtshilfe und Frauenheilkunde · 2025Article
- Prevalence of lower extremity edema following inguinal lymphadenectomy: A systematic review and meta-analysis.JPRAS open · 2025Review
- Role of Age, Comorbidity, and Frailty in the Prediction of Postoperative Complications After Surgery for Vulvar Cancer: A Retrospective Cohort Study with the Development of a Nomogram.Current oncology (Toronto, Ont.) · 2024Article
- Multidisciplinary Vulvar Cancer Management: The Dermatologist's Perspective.Life (Basel, Switzerland) · 2024Review
- Long-term outcomes of vulvar or vaginal cancer patients undergoing laparoendoscopic single-site inguinal lymphadenectomy.Journal of minimal access surgery · 2024Article
- Insulin Resistance: The Increased Risk of Cancers.Current oncology (Toronto, Ont.) · 2024Review
- Article
- Indocyanine green fluorescent image-guided inguinal sentinel lymph node biopsy in vulvar cancer.Obstetrics & gynecology science · 2022Article
- Lymphatic Function of the Lower Limb after Groin Dissection for Vulvar Cancer and Reconstruction with Lymphatic SCIP Flap.Cancers · 2022Article
- Radioisotope-Guided Sentinel Lymph Node Biopsy in Penile Cancer: A Long-Term Follow-Up Study.Frontiers in oncology · 2022Article
- VEGF-D Serum Level as a Potential Predictor of Lymph Node Metastasis and Prognosis in Vulvar Squamous Cell Carcinoma Patients.Frontiers in oncology · 2022Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe cornerstone of treatment in early-stage squamous cell carcinoma (SCC) of the vulva is surgery, predominantly consisting of wide local excision with elective uni- or bi-lateral inguinofemoral lymphadenectomy. This strategy is associated with a good prognosis, but also with impressive treatment-related morbidity. The aim of this study was to determine risk factors for the short-term (wound breakdown, infection and lymphocele) and long-term (lymphoedema and cellulitis/erysipelas) complications after groin surgery as part of the treatment of vulvar SCC.
methodsBetween January 1988 and June 2009, 164 consecutive patients underwent an inguinofemoral lymphadenectomy as part of their surgical treatment for vulvar SCC at the Department of Gynaecologic Oncology at the Radboud University Nijmegen Medical Centre. The clinical and histopathological data were retrospectively analysed.
resultsMultivariate analysis showed that older age, diabetes, 'en bloc' surgery and higher drain production on the last day of drain in situ gave a higher risk of developing short-term complications. Younger age and lymphocele gave higher risk of developing long-term complications. Higher number of lymph nodes dissected seems to protect against developing any long-term complications.
conclusionOur analysis shows that patient characteristics, extension of surgery and postoperative management influence short- and/or long-term complications after inguinofemoral lymphadenectomy in vulvar SCC patients. Further research of postoperative management is necessary to analyse possibilities to decrease the complication rate of inguinofemoral lymphadenectomy; although the sentinel lymph node procedure appears to be a promising technique, in 50% of the patients an inguinofemoral lymphadenectomy is still indicated.
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