ArticleInternational archives of medicine2011
Predictors of in-hospital mortality in elderly patients with bacteraemia admitted to an Internal Medicine ward.
Article in International archives of medicine, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Effects of Inappropriate Administration of Empirical Antibiotics on Mortality in Adults With Bacteraemia: Systematic Review and Meta-Analysis.Frontiers in medicine · 2022Pooled it
- Antimicrobial Susceptibility Patterns ofIndian journal of microbiology · 2024Article
- Blood-Stream Infections: Causative Agents, Antibiotic Resistance and Associated Factors in Older Patients.Materia socio-medica · 2024Article
- Molecular Epidemiology ofAntibiotics (Basel, Switzerland) · 2022Article
- Risk factors and mortality for elderly patients with bloodstream infection of carbapenem resistance Klebsiella pneumoniae: a 10-year longitudinal study.BMC geriatrics · 2022Article
- Bacteraemia and quick Sepsis Related Organ Failure Assessment (qSOFA) are independent risk factors for long-term mortality in very elderly patients with suspected infection: retrospective cohort study.BMC infectious diseases · 2022Article
- Disease burden and long-term trends of urinary tract infections: A worldwide report.Frontiers in public health · 2022Article
- Paediatric Antimicrobial Stewardship for Respiratory Infections in the Emergency Setting: A Systematic Review.Antibiotics (Basel, Switzerland) · 2021Review
- Bloodstream infections in the elderly: what is the real goal?Aging clinical and experimental research · 2021Review
- Early surgery may lower mortality in patients suffering from severe spinal infection.Acta neurochirurgica · 2020Article
- Remodeling of the Immune Response With Aging: Immunosenescence and Its Potential Impact on COVID-19 Immune Response.Frontiers in immunology · 2020Review
- The quick Sepsis-related Organ Failure Assessment (qSOFA) is a good predictor of in-hospital mortality in very elderly patients with bloodstream infections: A retrospective observational study.Scientific reports · 2019Observational
- Prevalence and factors associated with one-year mortality of infectious diseases among elderly emergency department patients in a middle-income country.BMC infectious diseases · 2019Article
- Infections and internal medicine patients: Could a comorbidity score predict in-hospital mortality?Medicine · 2018Observational
- Observational
- Association between dementia and reduced walking ability and 30-day mortality in patients with extended-spectrum beta-lactamase-producing Escherichia coli bacteremia.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2017Article
- Impact of appropriate empirical antibiotic treatment on recurrence and mortality in patients with bacteraemia: a population-based cohort study.BMC infectious diseases · 2017Article
- Observational
- Body Temperature at the Emergency Department as a Predictor of Mortality in Patients With Bacterial Infection.Medicine · 2016Observational
- Bloodstream infections in older patients.Virulence · 2016Review
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6 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundInfectious diseases are a common cause of increased morbidity and mortality in elderly patients. Bacteraemia in the elderly is a difficult diagnosis and a therapeutic challenge due to age-related vicissitudes and to their comorbidities. The main purpose of the study was to assess independent risk factors for in-hospital mortality among the elderly with bacteraemia admitted to an Internal Medicine Ward.
methodsOverall, a cohort of 135 patients, 65 years of age and older, with bacteraemia were retrospectively studied. Data related to demographic information, comorbidities, clinical parameters on admission, source and type of infection, microorganism isolated in the blood culture, laboratory data and empirical antibiotic treatment was recorded from each patient. Multivariate logistic regression was performed to identify independent predictors of all-cause in-hospital mortality.
resultsOf these 135 patients, 45.9% were women. The most common infections in this group of patients were urinary tract infections (46.7%). The main microorganisms isolated in the blood cultures were Escherichia coli (14.9%), Methicillin-resistant Staphylococcus aureus (MRSA) (12.0%), non-MRSA (11.4%), Klebsiella pneumoniae (9.1%) and Enterococcus faecalis (8.0%). The in-hospital mortality was 22.2%. Independent prognostic factors associated with in-hospital mortality were age ≥ 85 years, chronic renal disease, bacteraemia of unknown focus and cognitive impairment at admission (OR, 2.812 [95% CI, 1.039-7.611; p = 0.042]; OR, 6.179 [95% CI, 1.840-20.748; p = 0.003]; OR, 8.673 [95% CI, 1.557-48.311; p = 0.014] and OR, 3.621 [95% CI, 1.226-10.695; p = 0.020], respectively). By multivariate analysis appropriate antibiotic therapy was not associated with lower odds of mortality.
conclusionBacteraemia in the elderly has a high mortality rate. There are no set of signs or clinical features that can predict bacteraemia in the elderly. However, older age (≥ 85 years), chronic renal disease, bacteraemia of unknown focus and severe cognitive impairment adversely affects the outcome of elderly patients with bacteraemia admitted to an Internal Medicine ward.
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