Evidence map›Paper›PMID 21969875›Full record

Trial reportPloS one2011

High prevalence of self-reported undiagnosed HIV despite high coverage of HIV testing: a cross-sectional population based sero-survey in South Africa.

Katharina Kranzer, Nienke van Schaik, Unice Karmue, Keren Middelkoop, Elaine Sebastian, Stephen D Lawn, Robin Wood, Linda-Gail Bekker

Registry-linked trialAbstract readRandomized Controlled Trial
In one paragraph

Trial report in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03537872 (PROvide MIner-friendly SErvices for Integrated TB/HIV Care in Lesotho Study), which is not on this map. Cited by 34 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03537872 nacompletednot on this mapstarted 2018, after this paper: background citation

PROvide MIner-friendly SErvices for Integrated TB/HIV Care in Lesotho Study (PROMISE Study)

TypeinterventionalSponsorColumbia UniversityRan2018 to 2019Enrolled248ConditionsHIVArmsMiner-Friendly (MF) Service Venues TB/HIV Integration Strategies, Public Sector (PS) Health Facilities TB/HIV Integration Strategies
3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 3 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Katharina KranzerDepartment of Clinical Research Unit, London School of Hygiene and Tropical Medicine, London, United Kingdom. katharina.kranzer@lshtm.ac.uk
Nienke van Schaik
Unice Karmue
Keren Middelkoop
Elaine Sebastian
Stephen D Lawn
Robin Wood
Linda-Gail Bekker

Funding

Observational Antiretroviral Studies In Southern Africa (OASIS) CollaborationU01AI069924 · NIAID · UNIVERSITAT BERN · PI Cleophas Chimbetete, Mary-Ann Davies · 2006 to 2026
$55.9M
The effect of ART on rates and transmission of TBU19AI053217 · NIAID · WITS HEALTH CONSORTIUM (PTY), LTD · PI MCINTYRE, JAMES ALASDAIR · 2002 to 2011
$44.9M
Optimizing HIV Care in Less Developed CountriesR01AI058736 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI Kenneth Alan Freedberg, Emily Parker Hyle · 2004 to 2026
$21.5M
NIAID NIH HHS 1U19AI053217NIAID NIH HHS 5 R01 AI058736-02NIAID NIH HHS 5U01AI069924-02NIAID NIH HHS IU19AI53217-07NIAID NIH HHS R01 AI058736NIAID NIH HHS U01 AI069924NIAID NIH HHS U19 AI053217Wellcome Trust
6 · The paper itself

Abstract

objectivesTo measure HIV prevalence and uptake of HIV counseling and testing (HCT) in a peri-urban South African community. To assess predictors for previous HIV testing and the association between the yield of previously undiagnosed HIV and time of last negative HIV test

methodsA random sample of 10% of the adult population (≥15 years) were invited to attend a mobile HCT service. Study procedures included a questionnaire, HIV testing and CD4 counts. Predictors for previous testing were determined using a binominal model.

results1,144 (88.0%) of 1,300 randomly selected individuals participated in the study. 71.0% (68.3-73.6) had previously had an HIV test and 37.5% (34.6-40.5) had tested in the past 12 months. Men, migrants and older (>35 years) and younger (<20 years) individuals were less likely to have had a previous HIV test. Overall HIV prevalence was 22.7 (20.3-25.3) with peak prevalence of 41.8% (35.8-47.8) in women aged 25.1-35 years and 37.5% (26.7-48.3) in men aged 25.1-45 years. Prevalence of previously undiagnosed HIV was 10.3% (8.5-12.1) overall and 4.5% (2.3-6.6), 8.0% (CI 3.9-12.0) and 20.0% (13.2-26.8) in individuals who had their most recent HIV test within 1, 1-2 and more than 2 years prior to the survey.

conclusionThe high burden of undiagnosed HIV in individuals who had recently tested underscores the importance of frequent repeat testing at least annually. The high prevalence of previously undiagnosed HIV in individuals reporting a negative test in the 12 months preceding the survey indicates a very high incidence. Innovative prevention strategies are needed.

Indexed as

AdultAIDS SerodiagnosisCommunicable Disease ControlCommunity Health ServicesCross-Sectional StudiesFemaleHIV InfectionsHumansIncidenceMaleMass ScreeningMiddle AgedPrevalenceReproducibility of ResultsSouth Africa

Identifiers

PMID21969875
PMCPMC3182182

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.