ArticlePloS one2011
The worker honeybee fat body proteome is extensively remodeled preceding a major life-history transition.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 47 citations in OpenAlex.
- Article
- Impact of Monofloral Pollen Diets on the Development of Hypopharyngeal Glands and Modulation of Enzymatic, Non-Enzymatic, and Ionic Biomarker Activities in Selected Fat Body Segments and Hemolymph ofMolecules (Basel, Switzerland) · 2026Article
- Honeybee aging as an emergent property of a self-organizing dissipative system.Frontiers in systems biology · 2026Article
- Gut plasma membrane proteomes of adults and larvae of the European honey bee, Apis mellifera.Scientific reports · 2025Article
- Life-history stage determines the diet of ectoparasitic mites on their honey bee hosts.Nature communications · 2024Article
- Article
- Antimicrobial Activity of Apidermin 2 from the HoneybeeInsects · 2022Article
- The trophocytes and oenocytes of worker and queen honey bees (Apis mellifera) exhibit distinct age-associated transcriptome profiles.GeroScience · 2021Article
- Evaluating Effects of a Critical Micronutrient (24-Methylenecholesterol) on Honey Bee Physiology.Annals of the Entomological Society of America · 2020Article
- The Emerging Proteomic Research Facilitates in-Depth Understanding of the Biology of Honeybees.International journal of molecular sciences · 2019Review
- Appetite is correlated with octopamine and hemolymph sugar levels in forager honeybees.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2019Article
- Reproductive parasitism by worker honey bees suppressed by queens through regulation of worker mandibular secretions.Scientific reports · 2018Article
- DNA base modifications in honey bee and fruit fly genomes suggest an active demethylation machinery with species- and tissue-specific turnover rates.Biochemistry and biophysics reports · 2016Article
- Genomic Analyses Reveal Demographic History and Temperate Adaptation of the Newly Discovered Honey Bee Subspecies Apis mellifera sinisxinyuan n. ssp.Molecular biology and evolution · 2016Article
- Cytosine modifications in the honey bee (Apis mellifera) worker genome.Frontiers in genetics · 2015Review
- The dietary proportion of essential amino acids and Sir2 influence lifespan in the honeybee.Age (Dordrecht, Netherlands) · 2014Article
- Transcriptional markers of sub-optimal nutrition in developing Apis mellifera nurse workers.BMC genomics · 2014Article
- Soluble proteins of chemical communication: an overview across arthropods.Frontiers in physiology · 2014Review
- Comparative proteomics and expression analysis of five genes in Epicauta chinensis larvae from the first to fifth instar.PloS one · 2014Article
- Honey bee protein atlas at organ-level resolution.Genome research · 2013Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 3 countries.
Funding
Abstract
Honeybee workers are essentially sterile female helpers that make up the majority of individuals in a colony. Workers display a marked change in physiology when they transition from in-nest tasks to foraging. Recent technological advances have made it possible to unravel the metabolic modifications associated with this transition. Previous studies have revealed extensive remodeling of brain, thorax, and hypopharyngeal gland biochemistry. However, data on changes in the abdomen is scarce. To narrow this gap we investigated the proteomic composition of abdominal tissue in the days typically preceding the onset of foraging in honeybee workers. In order to get a broader representation of possible protein dynamics, we used workers of two genotypes with differences in the age at which they initiate foraging. This approach was combined with RNA interference-mediated downregulation of an insulin/insulin-like signaling component that is central to foraging behavior, the insulin receptor substrate (irs), and with measurements of glucose and lipid levels. Our data provide new insight into the molecular underpinnings of phenotypic plasticity in the honeybee, invoke parallels with vertebrate metabolism, and support an integrated and irs-dependent association of carbohydrate and lipid metabolism with the transition from in-nest tasks to foraging.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.