ArticleAnesthesiology research and practice2012
Lipid emulsion for local anesthetic systemic toxicity.
Article in Anesthesiology research and practice, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 114 citations in OpenAlex.
- Quadratus Lumborum Block Versus Transversus Abdominis Plane Block in Laparoscopic Colorectal Surgery: A Systematic Review and Meta-Analysis.Medicina (Kaunas, Lithuania) · 2026Pooled it
- Local Anaesthetic Systemic Toxicity in Dental and Oral and Maxillofacial Surgery: Safe Dosing, Combination Agents, and Emergency Management-A Narrative Review.Dentistry journal · 2026Review
- Cardiac Electrophysiologic Effects of Different Local Anesthetics in Langendorff-Perfused Rabbit Hearts.Cardiovascular toxicology · 2026Article
- Local anesthetic systemic toxicity: awareness, recognition, and risk mitigation in the emergency department.Clinical and experimental emergency medicine · 2024Article
- Efficacy and safety of phospholipid nanoparticles (VBI-S) in reversing intractable hypotension in patients with septic shock: a multicentre, open-label, repeated measures, phase 2a clinical pilot trial.EClinicalMedicine · 2024Article
- Wide-Awake Olecranon Fracture Fixation: Is it Possible?Journal of hand surgery global online · 2023Article
- Complications After Dental Sedation: A Myotonic Mystery Case Report.Anesthesia progress · 2022Review
- Sudden quadriparesis after non-overdose local anesthesia.International journal of emergency medicine · 2022Article
- Cardio Protective Effects of Lipid Emulsion against Ropivacaine-Induced Local Anesthetic Systemic Toxicity-An Experimental Study.Journal of clinical medicine · 2022Article
- A Case of Brainstem Anesthesia after Retrobulbar Block for Globe Rupture Repair.Case reports in anesthesiology · 2021Article
- Subclavian transcatheter aortic valve implantation (TAVI): superficial cervical plexus block combined with low-dose interscalene block.Canadian journal of anaesthesia = Journal canadien d'anesthesie · 2020Article
- Clinical Pharmacokinetics and Pharmacodynamics of Levobupivacaine.Clinical pharmacokinetics · 2020Review
- Article
- Total Spinal Anesthesia Following an Interscalene Block Treated with Intravenous Lipid Emulsion.Cureus · 2019Article
- Novel Approaches for Treating Pain in Children.Current oncology reports · 2019Review
- Real-world insights on the use of transversus abdominis plane block with liposomal bupivacaine in the multimodal management of somatic versus visceral pain in the colorectal surgery setting.Journal of pain research · 2018Article
- An Evidence-Based Opioid-Free Anesthetic Technique to Manage Perioperative and Periprocedural Pain.Ochsner journal · 2018Article
- Exploring the effect of intravenous lipid emulsion in acute methamphetamine toxicity.Iranian journal of basic medical sciences · 2017Article
- Dynamic contrast optical coherence tomography images transit time and quantifies microvascular plasma volume and flow in the retina and choriocapillaris.Biomedical optics express · 2016Article
- Cardiac Arrest after Local Anaesthetic Toxicity in a Paediatric Patient.Case reports in anesthesiology · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The accidental overdose of local anesthetics may prove fatal. The commonly used amide local anesthetics have varying adverse effects on the myocardium, and beyond a certain dose all are capable of causing death. Local anesthetics are the most frequently used drugs amongst anesthetists and although uncommon, local anaesthetic systemic toxicity accounts for a high proportion of mortality, with local anaesthetic-induced cardiac arrest particularly resistant to standard resuscitation methods. Over the last decade, there has been convincing evidence of intravenous lipid emulsions as a rescue in local anesthetic-cardiotoxicity, and anesthetic organisations, over the globe have developed guidelines on the use of this drug. Despite this, awareness amongst practitioners appears to be lacking. All who use local anesthetics in their practice should have an appreciation of patients at high risk of toxicity, early symptoms and signs of toxicity, preventative measures when using local anesthetics, and the initial management of systemic toxicity with intravenous lipid emulsion. In this paper we intend to discuss the pharmacology and pathophysiology of local anesthetics and toxicity, and the rationale for lipid emulsion therapy.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.