ArticlePharmacognosy magazine2011
Effect of cleistanthin A and B on adrenergic and cholinergic receptors.
Article in Pharmacognosy magazine, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
9 citing papers in PubMed, 17 citations in OpenAlex.
- Article
- Antiproliferative Compounds from Cleistanthus boivinianus from the Madagascar Dry Forest.Journal of natural products · 2015Article
- Evaluation of the antihypertensive activity and alpha adrenergic receptor interaction of cleistanthins A and B.Journal of basic and clinical pharmacy · 2014Article
- Sub-chronic toxicological evaluation of cleistanthin A and cleistanthin B from the leaves ofToxicology reports · 2014Article
- The effects of aqueous extract of Cleistanthus collinus (Roxb.) (Euphorbiaceae) leaves on rat blood pressure.Pharmacognosy research · 2012Article
- Diuretic effects of cleistanthin a and cleistanthin B from the leaves of cleistanthus collinus in wistar rats.Journal of young pharmacists : JYP · 2012Article
- Biodistribution properties of cleistanthin A and cleistanthin B using magnetic resonance imaging in a normal and tumoric animal model.Pharmacognosy magazine · 2012Article
- Molecular docking and ex vivo pharmacological evaluation of constituents of the leaves of Cleistanthus collinus (Roxb.) (Euphorbiaceae).Indian journal of pharmacology · 2012Article
- Rapid Preparative Isolation of Cleistanthin A from the Leaves ofJournal of pharmacy & bioallied sciencesArticle
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe aim was to study the in vitro and in silico interactions of cleistanthin A and B on the adrenergic and cholinergic receptors using isolated animal tissues and bioinformatics tools. MATERIALS AND
methodsThe alpha adrenergic receptor activities of cleistanthin A and B were studied in vitro using a guinea pig vas deferens preparation. The beta adrenergic receptor activities of cleistanthin A and B on an isolated rat heart were studied in vitro using a modified Langendorff apparatus. The effects of cleistanthin A and B on the nicotinic and muscarinic cholinergic receptors were studied in vitro using rabbit vas deferens and rabbit jejunum, respectively. All the drug responses were recorded using a data acquisition system through a variable force transducer. The receptor-ligand interactions of cleistanthin A and B with adrenergic and cholinergic receptor proteins were determined using the ArgusLab molecular modeling and drug docking program.
resultsCleistanthin A and B significantly inhibited the actions of the alpha adrenergic receptor and the nicotinic cholinergic receptor. Cleistanthin A and B shifted the dose-response curve to the right with an increased EC(50) value of phenylephrine and acetylcholine. Both cleistanthin A and B did not have any significant effect on the beta adrenergic and muscarinic cholinergic receptors.
conclusionCleistanthin A and B block the alpha adrenergic and nicotinic cholinergic receptors, but these compounds do not interact at all with the beta adrenergic and muscarinic cholinergic receptors.
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