ArticleExperimental biology and medicine (Maywood, N.J.)2011
Maternal hepatic growth response to pregnancy in the mouse.
Article in Experimental biology and medicine (Maywood, N.J.), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Gestation-Specific Changes in the Anatomy and Physiology of Healthy Pregnant Women: An Extended Repository of Model Parameters for Physiologically Based Pharmacokinetic Modeling in Pregnancy.Clinical pharmacokinetics · 2017Pooled it
- Exploratory assessment of preconception phthalate exposure on pregnancy and offspring health outcomes in mice.Journal of the Endocrine Society · 2026Article
- Maternal Organ Growth: How the Adult Intestine Remodels During Pregnancy and Lactation.Development, growth & differentiation · 2026Review
- Impact ofPlants (Basel, Switzerland) · 2025Article
- Evolution of Litter Size: Proximate and Ultimate Mechanisms.Integrative and comparative biology · 2024Review
- Impacts of low birthweight on kidney development and intergenerational growth of the offspring.iScience · 2024Article
- Adipose tissue-liver cross-talk: a route to hepatic dysfunction in pregnant women with obesity.Bioscience reports · 2024Review
- Kinin B1 receptor controls maternal adiponectin levels and influences offspring weight gain.iScience · 2023Article
- Periportal hepatocyte proliferation at midgestation governs maternal glucose homeostasis in mice.Communications biology · 2023Article
- Impact of high-fat diet and exposure to constant light on reproductive competence of female ICR mice.Biology open · 2023Article
- Gestational exposure to FireMaster® 550 (FM 550) disrupts the placenta-brain axis in a socially monogamous rodent species, the prairie vole (Microtus ochrogaster).Molecular and cellular endocrinology · 2023Article
- IGFBP2 expressing midlobular hepatocytes preferentially contribute to liver homeostasis and regeneration.Cell stem cell · 2023Article
- Maternal hepatocytes heterogeneously and dynamically exhibit developmental phenotypes partially via yes-associated protein 1 during pregnancy.American journal of physiology. Gastrointestinal and liver physiology · 2023Article
- Maternal hepatic immunology during pregnancy.Frontiers in immunology · 2023Review
- Activation of Proneuronal Transcription Factor Ascl1 in Maternal Liver Ensures a Healthy Pregnancy.Cellular and molecular gastroenterology and hepatology · 2022Article
- Pregnancy and weaning regulate human maternal liver size and function.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Immune Milieu Established by Postpartum Liver Involution Promotes Breast Cancer Liver Metastasis.Cancers · 2021Article
- Mucosal Immunity and Liver Metabolism in the Complex Condition of Lactation Insufficiency.Journal of human lactation : official journal of International Lactation Consultant Association · 2020Article
- Pregnancy facilitates maternal liver regeneration after partial hepatectomy.American journal of physiology. Gastrointestinal and liver physiology · 2020Article
- Changes in Liver Mechanical Properties and Water Diffusivity During Normal Pregnancy Are Driven by Cellular Hypertrophy.Frontiers in physiology · 2020Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Pregnancy is characterized by physiological adjustments in the maternal compartment. In this investigation, the influence of pregnancy on maternal liver was examined in CD-1 mice. Dramatic changes were observed in the size of the maternal liver during pregnancy. Livers doubled in weight from the non-pregnant state to day 18 of pregnancy. The pregnancy-induced hepatomegaly was a physiological event of liver growth confirmed by DNA content increase and detection of hepatocyte hyperplasia and hypertrophy. Growth of the liver was initiated following implantation and peaked at parturition. The expression and/or activities of key genes known to regulate liver regeneration, a phenomenon of liver growth compensatory to liver mass loss, were investigated. The results showed that pregnancy-dependent liver growth was associated with interleukin (IL)-6, tumor necrosis factor α, c-Jun and IL-1β, but independent of hepatocyte growth factor, fibroblast growth factor 1, tumor necrosis factor receptor 1, constitutive androstane receptor and pregnane X receptor. Furthermore, maternal liver growth was associated with the activation of hepatic signal transducer and activator of transcription 3, β-catenin and epidermal growth factor receptor, but pregnancy did not activate hepatic c-Met. The findings suggest that the molecular mechanisms regulating pregnancy-induced liver growth and injury-induced liver regeneration exhibit overlapping features but are not identical. In summary, the liver of the mouse adapts to the demands of pregnancy via a dramatic growth response driven by hepatocyte proliferation and size increase.
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