ArticleCold Spring Harbor protocols2011
High-resolution multiphoton imaging of tumors in vivo.
Article in Cold Spring Harbor protocols, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
49 citing papers in PubMed.
- Targeting CSF-1 signaling between tumor cells and macrophages at TMEM doorways inhibits breast cancer dissemination.Oncogene · 2025Article
- Signaling events at TMEM doorways provide potential targets for inhibiting breast cancer dissemination.bioRxiv : the preprint server for biology · 2024Article
- Intravital imaging to study cancer progression and metastasis.Nature reviews. Cancer · 2023Review
- SWIP-a stabilized window for intravital imaging of the murine pancreas.Open biology · 2022Article
- Monitoring and modulation of the tumor microenvironment for enhanced cancer modeling.Experimental biology and medicine (Maywood, N.J.) · 2022Review
- A non-toxic, reversibly released imaging probe for oral cancer that is derived from natural compounds.Scientific reports · 2021Article
- Dive into Single, Seek Out Multiple: Probing Cancer Metastases via Single-Cell Sequencing and Imaging Techniques.Cancers · 2021Review
- The role of the tumor microenvironment in tumor cell intravasation and dissemination.European journal of cell biology · 2020Article
- Intravital Imaging Techniques for Biomedical and Clinical Research.Cytometry. Part A : the journal of the International Society for Analytical Cytology · 2020Review
- Article
- Glucocorticoids promote breast cancer metastasis.Nature · 2019Article
- The metabolic axis of macrophage and immune cell polarization.Disease models & mechanisms · 2018Review
- Review of quantitative multiscale imaging of breast cancer.Journal of medical imaging (Bellingham, Wash.) · 2018Review
- Three-photon imaging using defect-induced photoluminescence in biocompatible ZnO nanoparticles.International journal of nanomedicine · 2018Article
- Engineering and physical sciences in oncology: challenges and opportunities.Nature reviews. Cancer · 2017Review
- Time-lapsed, large-volume, high-resolution intravital imaging for tissue-wide analysis of single cell dynamics.Methods (San Diego, Calif.) · 2017Article
- Blood vessel endothelium-directed tumor cell streaming in breast tumors requires the HGF/C-Met signaling pathway.Oncogene · 2017Article
- Review
- Direct evidence for cancer-cell-autonomous extracellular protein catabolism in pancreatic tumors.Nature medicine · 2017Article
- Extended Time-lapse Intravital Imaging of Real-time Multicellular Dynamics in the Tumor Microenvironment.Journal of visualized experiments : JoVE · 2016Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Analysis of the individual steps in metastasis is crucial if insights at the molecular level are to be linked to the cell biology of cancer. A technical hurdle to achieving the analysis of the individual steps of metastasis is the fact that, at the gross level, tumors are heterogeneous in both animal models and patients. Human primary tumors show extensive variation in all properties ranging from growth and morphology of the tumor through tumor-cell density in the blood and formation and growth of metastases. Methods capable of the direct visualization and analysis of tumor-cell behavior at single-cell resolution in vivo have become crucial in advancing the understanding of mechanisms of metastasis, the definition of microenvironment, and the markers related to both. This article discusses the use of high-resolution multiphoton imaging of tumors (specifically breast tumors in mice) in vivo.
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Registered trials
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