ArticleProceedings of the National Academy of Sciences of the United States of America2011
Animal-specific C-terminal domain links myeloblastosis oncoprotein (Myb) to an ancient repressor complex.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 20 citations in OpenAlex.
- Structure of a nucleosome-bound MuvB transcription factor complex reveals DNA remodelling.Nature communications · 2022Article
- Structure and function of MuvB complexes.Oncogene · 2022Review
- The MuvB complex binds and stabilizes nucleosomes downstream of the transcription start site of cell-cycle dependent genes.Nature communications · 2022Article
- A long lost key opens an ancient lock:Biology open · 2020Article
- An RNAi Screen for Genes Required for Growth ofG3 (Bethesda, Md.) · 2019Article
- Structural mechanism of Myb-MuvB assembly.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- TheBiology open · 2017Article
- Structural mechanisms of DREAM complex assembly and regulation.Genes & development · 2015Article
- The complex containing Drosophila Myb and RB/E2F2 regulates cytokinesis in a histone H2Av-dependent manner.Molecular and cellular biology · 2013Article
- Duplication and maintenance of the Myb genes of vertebrate animals.Biology open · 2013Article
- Epigenetic regulation of olfactory receptor gene expression by the Myb-MuvB/dREAM complex.Genes & development · 2012Article
- Drosophila lin-52 acts in opposition to repressive components of the Myb-MuvB/dREAM complex.Molecular and cellular biology · 2012Article
- The MuvB complex sequentially recruits B-Myb and FoxM1 to promote mitotic gene expression.Genes & development · 2012Article
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
Members of the Myb oncoprotein and E2F-Rb tumor suppressor protein families are present within the same highly conserved multiprotein transcriptional repressor complex, named either as Myb and synthetic multivuval class B (Myb-MuvB) or as Drosophila Rb E2F and Myb-interacting proteins (dREAM). We now report that the animal-specific C terminus of Drosophila Myb but not the more highly conserved N-terminal DNA-binding domain is necessary and sufficient for (i) adult viability, (ii) proper localization to chromosomes in vivo, (iii) regulation of gene expression in vivo, and (iv) interaction with the highly conserved core of the MuvB/dREAM transcriptional repressor complex. In addition, we have identified a conserved peptide motif that is required for this interaction. Our results imply that an ancient function of Myb in regulating G2/M genes in both plants and animals appears to have been transferred from the DNA-binding domain to the animal-specific C-terminal domain. Increased expression of B-MYB/MYBL2, the human ortholog of Drosophila Myb, correlates with poor prognosis in human patients with breast cancer. Therefore, our results imply that the specific interaction of the C terminus of Myb with the MuvB/dREAM core complex may provide an attractive target for the development of cancer therapeutics.
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