ArticleProceedings of the National Academy of Sciences of the United States of America2011
Premotor synaptic plasticity limited to the critical period for song learning.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 41 citations in OpenAlex.
- Differential morphology and distribution of GFAP astrocytes in vocal brain circuit in a songbird Southern house wren and humans.Frontiers in neuroanatomy · 2026Article
- Sensorimotor variability distinguishes early features of cognition in toddlers with autism.iScience · 2024Article
- Disinhibition enables vocal repertoire expansion after a critical period.Nature communications · 2024Article
- Long-term stability of single neuron activity in the motor system.Nature neuroscience · 2022Article
- Performance-Dependent Consolidation of Learned Vocal Changes in Adult Songbirds.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Seasonal regulation of singing-driven gene expression associated with song plasticity in the canary, an open-ended vocal learner.Molecular brain · 2021Article
- Brain-Derived Neurotrophic Factor Has a Transsynaptic Trophic Effect on Neural Activity in an Adult Forebrain Circuit.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Signatures of sex: Sex differences in gene expression in the vertebrate brain.Wiley interdisciplinary reviews. Developmental biology · 2020Review
- Variation in sequence dynamics improves maintenance of stereotyped behavior in an example from bird song.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Vocal practice regulates singing activity-dependent genes underlying age-independent vocal learning in songbirds.PLoS biology · 2018Article
- Singing activity-driven Arc expression associated with vocal acoustic plasticity in juvenile songbird.The European journal of neuroscience · 2018Article
- Vocal learning promotes patterned inhibitory connectivity.Nature communications · 2017Article
- Naturalistic stimulation drives opposing heterosynaptic plasticity at two inputs to songbird cortex.Nature neuroscience · 2015Article
- Frank Beach Award Winner: Steroids as neuromodulators of brain circuits and behavior.Hormones and behavior · 2014Review
- Article
- The basal ganglia is necessary for learning spectral, but not temporal, features of birdsong.Neuron · 2013Article
- Translating birdsong: songbirds as a model for basic and applied medical research.Annual review of neuroscience · 2013Review
- Task-related "cortical" bursting depends critically on basal ganglia input and is linked to vocal plasticity.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Physiological evidence consistent with reduced neuroplasticity in human adolescents born preterm.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Changing neuroestrogens within the auditory forebrain rapidly transform stimulus selectivity in a downstream sensorimotor nucleus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
Abstract
Synaptic plasticity has been hypothesized to underlie learning and memory. Understanding of how such plasticity might produce motor learning is limited, in part because of the paucity of model systems with a tractable learned behavior under control of a discrete neural circuit. Songbirds possess both of these traits, thereby providing an excellent model for studying vertebrate motor learning. We report unique evidence of long-term depression (LTD) in the juvenile songbird premotor robust nucleus of the arcopallium (RA). LTD induction at RA recurrent collateral synapses requires NMDA receptors, postsynaptic depolarization, and postsynaptic calcium, and can be reversed by high-frequency stimulation. In adult birds, which have exited the critical period for sensorimotor learning and cannot modify their song, we were no longer able to induce LTD at RA collateral synapses. Furthermore, testosterone-induced premature maturation of song in juveniles abolishes LTD. LTD in nucleus RA therefore makes an excellent candidate mechanism to mediate song learning during development and is well-suited to provide insight into other forms of vertebrate motor learning.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.