ArticleProceedings of the National Academy of Sciences of the United States of America2011
Thermodynamic basis for the genome to capsid charge relationship in viral encapsidation.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 63 citations in OpenAlex.
- Law and Order of Colloidal Tectonics: From Molecules to Self-Assembled Colloids.Molecules (Basel, Switzerland) · 2024Review
- Theoretical Studies on Assembly, Physical Stability, and Dynamics of Viruses.Sub-cellular biochemistry · 2024Review
- Electrostatic Theory of the Acidity of the Solution in the Lumina of Viruses and Virus-Like Particles.The journal of physical chemistry. B · 2023Article
- Packaging contests between viral RNA molecules and kinetic selectivity.PLoS computational biology · 2022Article
- RNA-Mediated Virus Assembly: Mechanisms and Consequences for Viral Evolution and Therapy.Annual review of biophysics · 2019Review
- Systematic analysis of biological roles of charged amino acid residues located throughout the structured inner wall of a virus capsid.Scientific reports · 2018Article
- Varieties of charge distributions in coat proteins of ssRNA+ viruses.Journal of physics. Condensed matter : an Institute of Physics journal · 2018Article
- Review
- Single Particle Observation of SV40 VP1 Polyanion-Induced Assembly Shows That Substrate Size and Structure Modulate Capsid Geometry.ACS chemical biology · 2017Article
- HBV maintains electrostatic homeostasis by modulating negative charges from phosphoserine and encapsidated nucleic acids.Scientific reports · 2016Article
- Additives for vaccine storage to improve thermal stability of adenoviruses from hours to months.Nature communications · 2016Article
- Modeling Effects of RNA on Capsid Assembly Pathways via Coarse-Grained Stochastic Simulation.PloS one · 2016Article
- A Thermodynamic Model for Genome Packaging in Hepatitis B Virus.Biophysical journal · 2015Article
- Mechanisms of virus assembly.Annual review of physical chemistry · 2015Review
- Pathways for virus assembly around nucleic acids.Journal of molecular biology · 2014Article
- Role of electrostatics in the assembly pathway of a single-stranded RNA virus.Journal of virology · 2014Article
- An allometric relationship between the genome length and virion volume of viruses.Journal of virology · 2014Article
- RNA control of HIV-1 particle size polydispersity.PloS one · 2014Article
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Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We establish an appropriate thermodynamic framework for determining the optimal genome length in electrostatically driven viral encapsidation. Importantly, our analysis includes the electrostatic potential due to the Donnan equilibrium, which arises from the semipermeable nature of the viral capsid, i.e., permeable to small mobile ions but impermeable to charged macromolecules. Because most macromolecules in the cellular milieu are negatively charged, the Donnan potential provides an additional driving force for genome encapsidation. In contrast to previous theoretical studies, we find that the optimal genome length is the result of combined effects from the electrostatic interactions of all charged species, the excluded volume and, to a very significant degree, the Donnan potential. In particular, the Donnan potential is essential for obtaining negatively overcharged viruses. The prevalence of overcharged viruses in nature may suggest an evolutionary preference for viruses to increase the amount of genome packaged by utilizing the Donnan potential (through increases in the capsid radius), rather than high charges on the capsid, so that structural stability of the capsid is maintained.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.