Trial reportThe Journal of physiology2011
Effect of muscle metaboreflex activation on spontaneous cardiac baroreflex sensitivity during exercise in humans.
Trial report in The Journal of physiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed.
- Breathing technique-dependent acute cardiopulmonary responses during squats in healthy females.Physiological reports · 2026Trial
- Metaboreflex activation delays heart rate recovery after aerobic exercise in never-treated hypertensive men.The Journal of physiology · 2016Trial
- Heart rate variability and blood pressure during dynamic and static exercise at similar heart rate levels.PloS one · 2013Trial
- Isometric Exercise Training and Arterial Hypertension: An Updated Review.Sports medicine (Auckland, N.Z.) · 2024Review
- Augmented sympathoexcitation slows postexercise heart rate recovery.Journal of applied physiology (Bethesda, Md. : 1985) · 2023Article
- Left ventricular mechanical, cardiac autonomic and metabolic responses to a single session of high intensity interval training.European journal of applied physiology · 2022Article
- Ischemic preconditioning of the muscle reduces the metaboreflex response of the knee extensors.European journal of applied physiology · 2022Article
- Combined influence of inspiratory loading and locomotor subsystolic cuff inflation on cardiovascular responses during submaximal exercise.Journal of applied physiology (Bethesda, Md. : 1985) · 2020Article
- Are Blood Pressure and Cardiovascular Stress Greater in Isometric or in Dynamic Resistance Exercise?Sports (Basel, Switzerland) · 2020Review
- Lower Systolic Blood Pressure in Normotensive Subjects is Related to Better Autonomic Recovery Following Exercise.Scientific reports · 2020Article
- Clinical safety of blood flow-restricted training? A comprehensive review of altered muscle metaboreflex in cardiovascular disease during ischemic exercise.American journal of physiology. Heart and circulatory physiology · 2020Review
- Effects of dynamic arm and leg exercise on muscle sympathetic nerve activity and vascular conductance in the inactive leg.Journal of applied physiology (Bethesda, Md. : 1985) · 2019Article
- Cardiovascular responses to leg muscle loading during head-down tilt at rest and after dynamic exercises.Scientific reports · 2019Article
- Spontaneous cardiac baroreflex sensitivity is enhanced during post-exercise ischemia in men but not in women.European journal of applied physiology · 2019Article
- The Effect of Anodal Transcranial Direct Current Stimulation Over Left and Right Temporal Cortex on the Cardiovascular Response: A Comparative Study.Frontiers in physiology · 2018Article
- Resting EEG Microstates and Autonomic Heart Rate Variability Do Not Return to Baseline One Hour After a Submaximal Exercise.Frontiers in neuroscience · 2018Article
- Anaerobic metabolism induces greater total energy expenditure during exercise with blood flow restriction.PloS one · 2018Article
- Baroreflex and neurovascular responses to skeletal muscle mechanoreflex activation in humans: an exercise in integrative physiology.American journal of physiology. Regulatory, integrative and comparative physiology · 2017Review
- Cardiac Baroreflex Variability and Resetting during Sustained Mild Effort.Frontiers in physiology · 2017Article
- Muscular contraction mode differently affects autonomic control during heart rate matched exercise.Frontiers in physiology · 2015Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We sought to determine whether the activation of metabolically sensitive skeletal muscle afferents (muscle metaboreflex) is a potential mechanism for the decrease in spontaneous cardiac baroreflex sensitivity (cBRS) during exercise in humans. In protocol 1, 15 male subjects (22 ± 1 years) performed steady-state leg cycling at low (26 ± 4 W) and moderate workloads (105 ± 7 W), under free-flow conditions and with partial flow restriction (bilateral thigh cuff inflation at 100 mmHg) to evoke muscle metaboreflex activation during exercise. In protocol 2, rhythmic handgrip exercise at 35% maximum voluntary contraction was performed with progressive upper arm cuff inflation (0, 80, 100 and 120 mmHg) to elicit graded metaboreflex activation. Both protocols were followed by post-exercise ischaemia (PEI) to isolate the muscle metaboreflex. Leg cycling-induced increases in HR and mean BP were augmented by partial flow restriction (P < 0.05 vs. free flow), while HR and mean BP both remained elevated during PEI (P < 0.05 vs. rest). Leg cycling evoked an intensity-dependent decrease in cBRS (16 ± 2, 7 ± 1 and 2 ± 0.2 ms mmHg(-1) at rest, low and moderate workloads, respectively; P < 0.05), which was further reduced with partial flow restriction (by -2.6 ± 0.8 and -0.4 ± 0.1 ms mmHg(-1) at low and moderate workloads). cBRS remained suppressed during PEI following leg cycling with partial flow restriction (4 ± 1 ms mmHg(-1); P < 0.05 vs. rest). cBRS was unchanged during handgrip under free-flow conditions, handgrip with partial flow restriction and PEI following handgrip (P > 0.05 vs. rest). These data indicate that the activation of metabolically sensitive skeletal muscle afferents (muscle metaboreflex) decreases cardiac baroreflex responsiveness during leg cycling exercise in humans.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.