SynthesisParasitology research2012
Inflammatory cytokines IFN-γ, IL-4, IL-13 and TNF-α alterations in schistosomiasis: a meta-analysis.
Synthesis in Parasitology research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.
- Meta-analysis of the diagnostic efficiency of the questionnaires screening for schistosomiasis.Parasitology research · 2015Pooled it
- Associations of Schistosoma mansoni Infection, Latent Tuberculosis, Host Interferon-γ Concentrations, and Praziquantel Treatment in Tanzanian Adults.The American journal of tropical medicine and hygiene · 2026Article
- Pharmacological Inhibition of c-Jun N-Terminal Kinase Activity Exacerbates Liver Damage in Schistosoma mansoni Infected Mice.Liver international : official journal of the International Association for the Study of the Liver · 2025Article
- The Role of Praziquantel in the Prevention and Treatment of Fibrosis Associated with Schistosomiasis: A Review.Journal of tropical medicine · 2022Review
- Immune modulation of Th1, Th2, and T-reg transcriptional factors differing from cytokine levels in Schistosoma japonicum infection.Parasitology research · 2018Article
- Allograft inflammatory factor-1 alleviates liver disease of BALB/c mice infected with Schistosoma japonicum.Parasitology research · 2014Article
- TGF beta and IL13 in Schistosomiasis mansoni associated pulmonary arterial hypertension; a descriptive study with comparative groups.BMC infectious diseases · 2014Article
- Plasma cytokine profile in tropical endomyocardial fibrosis: predominance of TNF-a, IL-4 and IL-10.PloS one · 2014Article
- Article
- In vivo schistosomicidal activity of three novels 8-hydroxyquinoline derivatives against adult and immature worms of Schistosoma mansoni.Parasitology research · 2013Article
- A boswellic acid-containing extract attenuates hepatic granuloma in C57BL/6 mice infected with Schistosoma japonicum.Parasitology research · 2013Article
- Immunomodulatory effect of R848 on cytokine production associated with Schistosoma mansoni infection.Parasitology research · 2013Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cytokines play an important role in the immunological pathogenesis of schistosomiasis. Schistosomiasis would be associated with an imbalance in inflammatory cytokines that leads to a decrease of T helper (Th) 1 and an increase of Th2 cytokine secretion. Corresponding data so far have been inconsistent, so we performed a meta-analysis to assess whether cytokine alterations were risk factors for schistosomiasis progression. We searched MEDLINE, EMBASE, and CNKI databases for literatures including abstracts, reviews, and reference lists. Our studies included assessment of cytokine concentrations in vivo plasma or serum and secretion of cytokines in vitro by peripheral blood leukocytes from schistosomiasis patients or infected individuals with schistosome. The prototypic Th1 and Th2 cytokines IFN-γ and interleukin (IL)-4 were assessed as well as IL-13 and tumor necrosis factor-alpha (TNF-α). The results implied that an increase occurs in TNF-α and IL-4 with schistosomiasis progression.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.