Evidence map›Paper›PMID 21968866›Full record

ArticleThe journal of nutrition, health & aging2011

Physical frailty predicts future cognitive decline - a four-year prospective study in 2737 cognitively normal older adults.

T W Auyeung, J S W Lee, T Kwok, J Woo

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The journal of nutrition, health & aging, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 119 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
119citing papers in PubMed, 9 pooled it
6.4field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

119 citing papers in PubMed, 9 syntheses or guidelines pooled it, 247 citations in OpenAlex.

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  5. Associations Between Aging-Related Changes in Grip Strength and Cognitive Function in Older Adults: A Systematic Review.The journals of gerontology. Series A, Biological sciences and medical sciences · 2019
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59 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

T W AuyeungS.H. Ho Centre for Gerontology and Geriatric, The Chinese University of Hong Kong and Pok Oi Hospital, Hong Kong, China. auyeungtw@cuhk.edu.hk
J S W Lee
T Kwok
J Woo
Chinese University of Hong Kong · CNPok Oi Hospital · HK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo examine the association between baseline frailty measurements and cognitive function 4 years later.

designProspective observational study.

settingCommunity.

participantsTwo thousand seven hundred and thirty seven cognitively normal older adults. MEASUREMENT: The appendicular muscle mass (ASM), hand grip strength, timed chair-stand test, walking speed and step length were measured at baseline. The Mini-mental state examination (MMSE) was administered at baseline and 4 years later.

resultsIn men, all baseline frailty measurements, namely, being underweight, lower ASM, weaker grip strength, slower chair-stand test, shorter step length, slower timed walk were significantly associated with a lower MMSE score 4 years afterwards. After adjustment for age, years of education and baseline MMSE score, ASM and timed walk became insignificant. In women, all frailty measurements except underweight and low ASM were significantly associated with MMSE score 4 years later. Moreover, only weaker grip strength persisted to be significant after adjustment for age, years of education and baseline MMSE score.

conclusionPhysical frailty, as represented by being underweight, weaker grip strength, slower chair-stand test, shorter step-length in men and weaker grip strength in women, was associated with cognitive decline over a four year period.

Indexed as

Geriatric AssessmentHand StrengthPhysical FitnessAgedCognition DisordersFemaleFrail ElderlyGaitHumansMaleMuscle, SkeletalMuscle WeaknessOrgan SizePostureProspective StudiesReference Values

Identifiers

PMID21968866
PMCPMC12878988
OpenAlexW2024087673

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.