ArticleThe journal of nutrition, health & aging2011
Incidence and predictive factors of depressive symptoms in Alzheimer's disease: the REAL.FR study.
Article in The journal of nutrition, health & aging, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Prevalence of Behavioral and Psychological Symptoms of Dementia in Community-Dwelling Dementia Patients: A Systematic Review.Frontiers in psychiatry · 2021Pooled it
- Ambient bright light treatment improved proxy-rated sleep but not sleep measured by actigraphy in nursing home patients with dementia: a placebo-controlled randomised trial.BMC geriatrics · 2021Trial
- Factors Associated With Behavioral and Psychological Symptoms of Dementia: Prospective Observational Study Using Actigraphy.Journal of medical Internet research · 2021Observational
- A cross-national study of depression in preclinical dementia: A COSMIC collaboration study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2020Article
- An Actigraphy-Based Validation Study of the Sleep Disorder Inventory in the Nursing Home.Frontiers in psychiatry · 2020Article
- Linking late life depression and Alzheimer's disease: mechanisms and resilience.Current behavioral neuroscience reports · 2019Article
- Insomnia and dementia: is agomelatine treatment helpful? Case report and review of the literature.Therapeutic advances in psychopharmacology · 2016Article
- Sleep problems associated with behavioral and psychological symptoms as well as cognitive functions in Alzheimer's disease.Journal of clinical neurology (Seoul, Korea) · 2014Article
- Vascular risk factors and neuropsychiatric symptoms in Alzheimer's disease: the Cache County Study.International journal of geriatric psychiatry · 2014Article
- Behavioral and psychological symptoms in Alzheimer's disease.BioMed research international · 2014Review
- Behavioral management in the person with dementia.The journal of nutrition, health & aging · 2013Article
- Trajectories of Depressive Symptomatology in Rural Memory Clinic Patients between Baseline Diagnosis and 1-Year Follow-Up.Dementia and geriatric cognitive disorders extraArticle
- Risk of depression in persons with Alzheimer's disease: A national cohort study.Alzheimer's & dementia (Amsterdam, Netherlands)Article
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMany patients develop psychiatric and behavioral disturbances in the course of Alzheimer's disease (AD). Among these disturbances, depressive symptoms are frequent and affect nearly 40% of patients. The natural history and course of such symptoms in AD, and in particular the predictive factors, are little known. We studied the incidence and risk factors for the development of the first depressive symptoms in AD.
designMulticenter prospective study.
participantsThree hundred twelve AD patients from the French Network on AD (REAL.FR) without depression and without antidepressant treatment at baseline were followed up and assessed every 6 months for 4 years. During follow-up, all events occurring between two visits were carefully recorded. MEASUREMENTS: We used the Neuropsychiatric Inventory (NPI) for comprehensive evaluation of behavioral and psychological symptoms and depressive symptoms in particular. A multivariate analysis was performed using a backward stepwise Cox proportional hazards model.
resultsThe incidence of depressive symptoms was 17.45% person/years, 95%CI (13.88-21.02). Among non-time dependent variables, duration of disease (RR=0.51; 95%CI: 0.30-0.85, p=0.0102) and the number of comorbid conditions (RR=0.45; 95%CI: 0.24-0.83, p=0.0115) were protective factors against the development of depressive symptoms. Agitation/aggression (RR=1.96; 95%CI: 1.19-3.23, p=0.0078) and sleep disturbances (RR=2.65; 95%CI: 1.40-5.00, p=0.0026) were time-dependent variables predictive of depressive symptoms.
conclusionBetter knowledge of predictive factors of mood disturbances in AD will enable clinicians to set up appropriate management of their patients. As published longitudinal studies are few, further works should be carried out to improve knowledge of the pattern and course of depression and depressive symptoms in AD.
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