ArticleInternational journal of biochemistry and molecular biology2011
Regulation of cellular function by connexin hemichannels.
Article in International journal of biochemistry and molecular biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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Who cites it
17 citing papers in PubMed.
- Beyond the gap: moonlighting functions of connexins in cancer.Cell communication and signaling : CCS · 2026Review
- Antiproliferative effect of boldine on neural progenitor cells and on glioblastoma cells.Frontiers in neuroscience · 2023Article
- Article
- Connexin hemichannels regulate redox potential via metabolite exchange and protect lens against cellular oxidative damage.Redox biology · 2021Article
- Connexin Hemichannels Contribute to the Activation of cAMP Signaling Pathway and Renin Production.International journal of molecular sciences · 2020Article
- Computational physiology of uterine smooth muscle.Science progress · 2019Article
- Connexin 43 regulates the expression of wound healing-related genes in human gingival and skin fibroblasts.Experimental cell research · 2018Article
- Gating of Connexin Channels by transjunctional-voltage: Conformations and models of open and closed states.Biochimica et biophysica acta. Biomembranes · 2018Review
- Connexin 43 Hemichannels Regulate the Expression of Wound Healing-Associated Genes in Human Gingival Fibroblasts.Scientific reports · 2017Article
- Suppression of spinal connexin 43 expression attenuates mechanical hypersensitivity in rats after an L5 spinal nerve injury.Neuroscience letters · 2014Article
- Intrathecal carbenoxolone inhibits neuropathic pain and spinal wide-dynamic range neuronal activity in rats after an L5 spinal nerve injury.Neuroscience letters · 2014Article
- Human articular chondrocytes express multiple gap junction proteins: differential expression of connexins in normal and osteoarthritic cartilage.The American journal of pathology · 2013Article
- Spinal astrocyte gap junctions contribute to oxaliplatin-induced mechanical hypersensitivity.The journal of pain · 2013Article
- Hepatocyte polarity.Comprehensive Physiology · 2013Review
- The role of connexins in prostate cancer promotion and progression.Nature reviews. Urology · 2012Review
- Prevention of postoperative atrial fibrillation: novel and safe strategy based on the modulation of the antioxidant system.Frontiers in physiology · 2012Article
- Connexins and pannexins: Coordinating cellular communication in the testis and epididymis.Spermatogenesis · 2011Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Gap junctions and hemichannels are formed by a family of proteins called connexins. Till date up to twenty one different connexins have been characterized and their expression was observed to be spatio-temporally regulated. Gap junctions and hemichannels are involved in transfer of a variety of less than 1 kDa small molecules such as, ions, small metabolites, cAMP, ATP, IP3, prostaglandins, etc. Post-translational modifications of connexins and their interaction with other proteins are reported to be the key regulators of channel functions. Studies during the past decade or so, suggest the physiological important of connexin hemichannels mediating the communication between the cell and its environment. Molecules conveyed through the hemichannels elicit a variety of signaling pathways and influence cellular functions such as, cell cycle, tissue homeostasis, migration, mechanotransduction, oxidative stress. The purpose of the current review is to compile the reported studies so far and provide a general overview in our understanding how the molecular transfer through hemichannels regulates cellular signaling and functions.
Identifiers
21968837PMC3180094What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.