Evidence map›Paper›PMID 21968816›Full record

ReviewCurrent osteoporosis reports2011

Rickets.

M Zulf Mughal

Registry-linked trialAbstract readReview
PubMed Publisher
In one paragraph

Review in Current osteoporosis reports, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02301520 (Vitamin D Deficiency, Iodine Deficiency and Lead Levels in Haitian Infants and Children.), which is not on this map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
3.2field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02301520 completednot on this mapstarted 2015, after this paper: background citation

Vitamin D Deficiency, Iodine Deficiency and Lead Levels in Haitian Infants and Children.

TypeobservationalSponsorBoston Children's HospitalRan2015 to 2015Enrolled299ConditionsVitamin D Deficiency, Iodine Deficiency, Hypothyroidism, Rickets
3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 47 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Management of rickets: the new horizons for the pediatrician.Journal of health, population, and nutrition · 2025
    Review
  7. Article
  8. Article
  9. Review
  10. Mineral Metabolism in Children: Interrelation between Vitamin D and FGF23.International journal of molecular sciences · 2023
    Review
  11. Article
  12. Review
  13. Approach to Hypophosphatemic Rickets.The Journal of clinical endocrinology and metabolism · 2022
    Article
  14. Observational
  15. Review
  16. Article
  17. Article
  18. An Overview of Rickets in Children.Kidney international reports · 2020
    Review
  19. Article
  20. The aetiology of rickets-like lower limb deformities in Malawian children.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2016
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

M Zulf MughalDepartment of Paediatric Endocrinology, Royal Manchester Children's Hospital, Central Manchester University Hospitals NHS Foundation Trust, Oxford Road, Manchester, M13 9WL, UK. zulf.mughal@cmft.nhs.uk
Royal Manchester Children's Hospital · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Rickets is disorder of a growing child arising from disorders that result in impaired apoptosis of hypertrophic cells and mineralization of the growth plate. Rickets due to nutritional causes remains an important global problem. The factors responsible for resurgence of rickets among dark-skinned infants living in developed countries include the following: residence in northern or southern latitudes, voluntary avoidance of exposure to solar ultraviolet B radiation, maternal vitamin D deficiency during pregnancy, and prolonged breastfeeding without provision of vitamin D supplements. Fibroblast growth factor 23 (FGF23), secreted by osteocytes, is an important regulator of serum phosphate and 1,25(OH)(2)D(3) levels. Hypophosphatemic rickets resulting from increased synthesis or under-catabolism of FGF23 is reviewed.

Indexed as

RicketsAdolescentChildChild, PreschoolFibroblast Growth Factor-23Fibroblast Growth FactorsGrowth PlateHumansInfantInfant, NewbornNutritional StatusPhosphatesVitamin D DeficiencyFGF23 protein, humanFibroblast Growth Factor-23Fibroblast Growth FactorsPhosphates

Identifiers

PMID21968816
OpenAlexW4241060316

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.