SynthesisInternational orthopaedics2012
Clinical outcome after microfracture of the knee: a meta-analysis of before/after-data of controlled studies.
Synthesis in International orthopaedics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Systematic Review and Meta-Analysis of the Clinical Evidence on the Use of Autologous Matrix-Induced Chondrogenesis in the Knee.Cartilage · 2021Pooled it
- Effect of concurrent repair of medial meniscal posterior root tears during high tibial osteotomy for medial osteoarthritis during short-term follow-up: a systematic review and meta-analysis.BMC musculoskeletal disorders · 2021Pooled it
- A meta-analysis of clinical and radiographic outcomes of posterior horn medial meniscus root repairs.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2016Pooled it
- Norwegican Cartilage Project - a study protocol for a double-blinded randomized controlled trial comparing arthroscopic microfracture with arthroscopic debridement in focal cartilage defects in the knee.BMC musculoskeletal disorders · 2016Trial
- Cartilage extra-cellular matrix biomembrane for the enhancement of microfractured defects.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2014Trial
- Cartilage Defect Treatment Using High-Density Autologous Chondrocyte Implantation (HD-ACI).Bioengineering (Basel, Switzerland) · 2023Review
- Return to Pivoting Sports after Cartilage Repair Surgery of the Knee: A Scoping Review.Cartilage · 2023Article
- Current and Novel Therapeutics for Articular Cartilage Repair and Regeneration.Therapeutics and clinical risk management · 2023Review
- Observational
- Microdrilling Demonstrates Superior Patient-Reported Outcomes and Lower Revision Rates Than Traditional Microfracture: A Matched Cohort Analysis.Arthroscopy, sports medicine, and rehabilitation · 2021Article
- Are Weightbearing Restrictions Required After Microfracture for Isolated Chondral Lesions of the Knee? A Review of the Basic Science and Clinical Literature.Sports health · 2021Review
- The state of cartilage regeneration: current and future technologies.Current reviews in musculoskeletal medicine · 2015Article
- Treatment for cartilage injuries of the knee with a new treatment algorithm.World journal of orthopedics · 2014Review
- Cartilage repair in the knee with subchondral drilling augmented with a platelet-rich plasma-immersed polymer-based implant.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2014Article
- A 5-year follow-up after cartilage repair in the knee using a platelet-rich plasma-immersed polymer-based implant.The open orthopaedics journal · 2014Article
- Anterior cruciate ligament deficiency leads to early instability of scaffold for cartilage regeneration: a controlled laboratory ex-vivo study.International orthopaedics · 2012Article
- Long-term outcome of grade III and IV chondral injuries of the knee treated with Steadman microfracture technique.Clinical cases in mineral and bone metabolism : the official journal of the Italian Society of Osteoporosis, Mineral Metabolism, and Skeletal DiseasesArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe aims of this study were to systematically review the medical literature, in order to find controlled studies about microfracture in the treatment of patients with full-thickness cartilage lesions of the knee, to statistically combine these studies in order to determine a best estimate of the average treatment effect, and to gather information to detect cartilage-specific and patient-specific factors that might have an influence on the clinical outcome.
methodsWe searched four electronic databases for controlled clinical trials or controlled prospective observational studies. We pooled before/after-data of study arms using the term microfracture.
resultsWe calculated an overall best estimate of 1.106, with [0.566; 1.646] as 95% confidence interval of the mean standardized treatment effect for a representative patient population.
conclusionsOur meta-analysis revealed a clinically relevant improvement of the postoperative clinical status as compared to the preoperative status. An increase of 22 overall KOOS points may provide a rough estimate for the mean expected treatment effect achieved by microfracturing.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.