ArticleHypertension (Dallas, Tex. : 1979)2011
Intensified effect of adiposity on blood pressure in overweight and obese children.
Article in Hypertension (Dallas, Tex. : 1979), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
66 citing papers in PubMed, 2 syntheses or guidelines pooled it, 143 citations in OpenAlex.
- Hypertension in Children and Adolescents: A Position Statement From a Panel of Multidisciplinary Experts Coordinated by the French Society of Hypertension.Frontiers in pediatrics · 2021Pooled it
- Relationship between different levels of the Mexican food environment and dietary intake: a qualitative systematic review.Public health nutrition · 2020Pooled it
- The intake assessment of diverse dietary patterns on childhood hypertension: alleviating the blood pressure and lipidemic factors with low-sodium seafood rich in omega-3 fatty acids.Lipids in health and disease · 2020Trial
- Childhood Obesity: A Multisystem Challenge Linking Hypertension, NAFLD, and Sleep Apnea.Medical sciences (Basel, Switzerland) · 2026Review
- Inadequate sleep is a risk factor for pediatric hypertension: the pathophysiologic and socioeconomic correlates.Pediatric research · 2026Review
- Factors Related to Hypertension in Pediatric Patients Who Do Not Have Obstructive Sleep Apnea: A Retrospective Chart Study.Journal of clinical medicine · 2025Article
- Development and Validation of a Nomogram-Based Model to Predict Primary Hypertension Within the Next Year in Children and Adolescents: Retrospective Cohort Study.Journal of medical Internet research · 2024Article
- The ongoing impact of obesity on childhood hypertension.Pediatric nephrology (Berlin, Germany) · 2024Review
- Four-year longitudinal associations of physical activity, waist circumference, and blood pressure in UK adolescents.Pediatric research · 2024Article
- Childhood Obesity: Insight into Kidney Involvement.International journal of molecular sciences · 2023Review
- Nutrition, Body Composition, and Blood Pressure in Children and Adolescents from the Korea National Health and Nutrition Examination Survey.International journal of environmental research and public health · 2022Article
- Prevalence of and Factors Associated With High Blood Pressure Among Adolescents in India.JAMA network open · 2022Article
- High Blood Pressure in Children and Adolescents: Current Perspectives and Strategies to Improve Future Kidney and Cardiovascular Health.Kidney international reports · 2022Review
- Approach to Hypertension in Adolescents and Young Adults.Current cardiology reports · 2022Review
- Proposition of Cutoff Points for Anthropometric Indicators to Identify High Blood Pressure in Adolescents.Frontiers in nutrition · 2022Article
- Measures of ejection duration and subendocardial viability ratio in normal weight and overweight adolescent children.Physiological reports · 2021Article
- Trends in Blood Pressure and Hypertension Among US Children and Adolescents, 1999-2018.JAMA network open · 2021Article
- Hypertension in adolescents and young adults referred to a tertiary hypertension clinic in Cape Town, South Africa.Medicine · 2020Article
- Comparison of nonlinear curves and surfaces.Computational statistics & data analysis · 2020Article
- Obstructive sleep apnea and blood pressure in young hypertensives: does it matter?Internal and emergency medicine · 2020Article
6 more citing papers are in PubMed but not listed here.
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
In children, blood pressure (BP) and risk for hypertension are proportional to degree of adiposity. Whether the relationship to BP is similar over the full range of adiposity is less clear. Subjects from a cohort study (n=1111; 50% male and 42% black) contributed 9102 semiannual BP and height/weight assessments. The mean enrollment age was 10.2 years, and mean follow-up was 4.5 years. Adiposity was expressed as body mass index percentile, which accounted for effects of age and sex. The following observations were made. The effect of relative adiposity on BP was minimal until the body mass index percentile reached 85, beginning of the overweight category, at which point the effect of adiposity on BP increased by 4-fold. Similarly intensified adiposity effects on BP were observed in children aged ≤10, 11 to 14 years, and ≥15 years. Serum levels of the adipose tissue-derived hormone, leptin, together with heart rate, showed an almost identically patterned relation to BP to that of body mass index percentile and BP, thus implicating a possible mediating role for leptin. In conclusion, there is a marked intensification of the influence of adiposity on BP when children reach the categories of overweight and obese. Among the possible pathways, leptin may be a potentially important mediator acting through the sympathetic nervous system (reflected in heart rate). The findings have relevance to interventions designed to prevent or treat adiposity-related increases in BP and to the analytic approaches used in epidemiological studies.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.