ArticleThe Journal of clinical investigation2011
Viruses and human brain tumors: cytomegalovirus enters the fray.
Article in The Journal of clinical investigation, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
6 citing papers in PubMed, 14 citations in OpenAlex.
- Biology and Clinical Relevance of HCMV-Associated Adaptive NK Cells.Frontiers in immunology · 2022Review
- Medulloblastoma: Tumor Biology and Relevance to Treatment and Prognosis Paradigm.Current neurology and neuroscience reports · 2016Review
- Detection of human cytomegalovirus in different histopathological types of glioma in Iraqi patients.BioMed research international · 2015Article
- Absence of human cytomegalovirus infection in childhood brain tumors.American journal of cancer research · 2015Article
- Does the existence of HCMV components predict poor prognosis in glioma?Journal of neuro-oncology · 2014Article
- High human cytomegalovirus antigen expression in pediatric medulloblastoma tissue is associated with poor event-free survival.Neuro-oncology advancesArticle
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Medulloblastoma is the most common malignant brain tumor in children. Overall survival rates have improved in recent years as a result of risk-stratified treatment regimens. However, medulloblastoma remains associated with substantial mortality, and survivors often experience debilitating neurological, endocrinological, and social sequelae as a result of treatment. Targeted and less toxic therapeutic strategies are therefore needed. In this issue of the JCI, Baryawno et al. report their findings that a large percentage of primary medulloblastomas and medulloblastoma cell lines are infected with human cytomegalovirus (HCMV) and suggest that targeting this virus could provide a new way to treat individuals with medulloblastoma.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.