ArticleBrain research bulletin2011
Developmental exposure to organophosphates triggers transcriptional changes in genes associated with Parkinson's disease in vitro and in vivo.
Article in Brain research bulletin, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.
- Evaluation of developmental toxicity of chlorpyrifos through new approach methodologies: a systematic review.Archives of toxicology · 2025Pooled it
- Epidemiology meets toxicogenomics: Mining toxicologic evidence in support of an untargeted analysis of pesticides exposure and Parkinson's disease.Environment international · 2022Article
- Persistent neurobehavioral and neurochemical anomalies in middle-aged rats after maternal diazinon exposure.Toxicology · 2022Article
- Food Contamination: An Unexplored Possible Link between Dietary Habits and Parkinson's Disease.Nutrients · 2022Review
- Preventing Parkinson's Disease: An Environmental Agenda.Journal of Parkinson's disease · 2022Review
- Postnatal zinc or paraquat administration increases paraquat or zinc-induced loss of dopaminergic neurons: insight into augmented neurodegeneration.Molecular and cellular biochemistry · 2020Article
- MicroRNAs alteration as early biomarkers for cancer and neurodegenerative diseases: New challenges in pesticides exposure.Toxicology reports · 2020Article
- Timescales of developmental toxicity impacting on research and needs for intervention.Basic & clinical pharmacology & toxicology · 2019Review
- Specific Effects of Chronic Dietary Exposure to Chlorpyrifos on Brain Gene Expression-A Mouse Study.International journal of molecular sciences · 2017Article
- Developmental neurotoxicity of succeeding generations of insecticides.Environment international · 2017Review
- Parkinsonism Signs and Symptoms in Agricultural Pesticide Handlers in Washington State.Journal of agromedicine · 2017Article
- P-Glycoprotein Transport of Neurotoxic Pesticides.The Journal of pharmacology and experimental therapeutics · 2015Article
- Differentiating neurons derived from human umbilical cord blood stem cells work as a test system for developmental neurotoxicity.Molecular neurobiology · 2015Article
- Blood α-synuclein in agricultural pesticide handlers in central Washington State.Environmental research · 2015Article
- Does mechanism matter? Unrelated neurotoxicants converge on cell cycle and apoptosis during neurodifferentiation.Neurotoxicology and teratology · 2012Article
- Developmental neurotoxicity of organophosphates targets cell cycle and apoptosis, revealed by transcriptional profiles in vivo and in vitro.Neurotoxicology and teratology · 2012Article
- Acute and developmental behavioral effects of flame retardants and related chemicals in zebrafish.Neurotoxicology and teratologyArticle
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Epidemiologic studies support a connection between organophosphate pesticide exposures and subsequent risk of Parkinson's disease (PD). We used differentiating, neuronotypic PC12 cells to compare organophosphates (chlorpyrifos, diazinon), an organochlorine (dieldrin) and a metal (Ni(2+)) for their effects on the transcription of PD-related genes. Both of the organophosphates elicited significant changes in gene expression but with differing patterns: chlorpyrifos evoked both up- and downregulation whereas diazinon elicited overall reductions in expression. Dieldrin was without effect but Ni(2+) produced a pattern resembling that of diazinon. We then exposed neonatal rats to chlorpyrifos or diazinon for the first 4 days after birth and examined the expression of PD-related genes in the brainstem and forebrain. Chlorpyrifos had no significant effect whereas diazinon produced significant increases and decreases in expression of the same PD genes that were targeted in vitro. Our results provide some of the first evidence for a mechanistic relationship between developmental organophosphate exposure and the genes known to confer PD risk in humans; but they also point to disparities between different organophosphates that reinforce the concept that their neurotoxic actions do not rest solely on their shared property as cholinesterase inhibitors. The parallel effects of diazinon and Ni(2+) also show how otherwise unrelated developmental neurotoxicants can nevertheless produce similar outcomes by converging on common molecular pathways, further suggesting a need to examine metals such as Ni(2+) as potential contributors to PD risk.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.