ArticleExperimental physiology2012
The role of the subfornical organ in angiotensin II-salt hypertension in the rat.
Article in Experimental physiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 47 citations in OpenAlex.
- Acute hypernatremia increases functional connectivity of NaCl sensing regions in the human brain: An fMRI pilot study.Autonomic neuroscience : basic & clinical · 2024Article
- Physiological Mechanisms of Dietary Salt Sensing in the Brain, Kidney, and Gastrointestinal Tract.Hypertension (Dallas, Tex. : 1979) · 2024Review
- Neurons of the median preoptic nucleus contribute to chronic angiotensin II-salt induced hypertension in the rat.Physiological reports · 2022Article
- DOCA-salt hypertension and the role of the OVLT-sympathetic-gut microbiome axis.Clinical and experimental pharmacology & physiology · 2021Article
- Expression and function of nesfatin-1 are altered by stage of the estrous cycle.American journal of physiology. Regulatory, integrative and comparative physiology · 2019Article
- Lesion of the OVLT markedly attenuates chronic DOCA-salt hypertension in rats.American journal of physiology. Regulatory, integrative and comparative physiology · 2018Article
- Central administration of TRV027 improves baroreflex sensitivity and vascular reactivity in spontaneously hypertensive rats.Clinical science (London, England : 1979) · 2018Article
- Measurement of cations, anions, and acetate in serum, urine, cerebrospinal fluid, and tissue by ion chromatography.Physiological reports · 2018Article
- Blood-borne interleukin-1β acts on the subfornical organ to upregulate the sympathoexcitatory milieu of the hypothalamic paraventricular nucleus.American journal of physiology. Regulatory, integrative and comparative physiology · 2018Article
- The proinflammatory cytokine tumor necrosis factor-α excites subfornical organ neurons.Journal of neurophysiology · 2017Article
- Chronic high-sodium diet intake after weaning lead to neurogenic hypertension in adult Wistar rats.Scientific reports · 2017Article
- Hypothalamic Signaling in Body Fluid Homeostasis and Hypertension.Current hypertension reports · 2017Review
- Hypothalamic and inflammatory basis of hypertension.Clinical science (London, England : 1979) · 2017Review
- Activation of neuronal endothelin B receptors mediates pressor response through alpha-1 adrenergic receptors.Physiological reports · 2017Article
- Organum Vasculosum of the Lamina Terminalis Detects NaCl to Elevate Sympathetic Nerve Activity and Blood Pressure.Hypertension (Dallas, Tex. : 1979) · 2017Article
- Possible role for brain prostanoid pathways in the development of angiotensin II-salt hypertension in rats.American journal of physiology. Regulatory, integrative and comparative physiology · 2016Article
- Neuroinflammatory and autonomic mechanisms in diabetes and hypertension.American journal of physiology. Endocrinology and metabolism · 2016Review
- DREADD-induced activation of subfornical organ neurons stimulates thirst and salt appetite.Journal of neurophysiology · 2016Article
- Angiotensin II-Induced Hypertension Is Attenuated by Overexpressing Copper/Zinc Superoxide Dismutase in the Brain Organum Vasculosum of the Lamina Terminalis.Oxidative medicine and cellular longevity · 2016Article
- Role of neurons and glia in the CNS actions of the renin-angiotensin system in cardiovascular control.American journal of physiology. Regulatory, integrative and comparative physiology · 2015Review
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Hypertension caused by chronic infusion of angiotensin II (Ang II) in experimental animals is dependent, in part, on increased activity of the sympathetic nervous system. This chronic sympathoexcitatory response is amplified by a high-salt diet, suggesting an interaction of circulating Ang II and dietary salt on sympathetic regulatory pathways in the brain. The present study tested the hypothesis that the subfornical organ (SFO), a forebrain circumventricular organ known to be activated by circulating Ang II, is crucial to the pathogenesis of hypertension induced by chronic Ang II administration in rats on a high-salt diet (Ang II-salt model). Rats were randomly selected to undergo either subfornical organ lesion (SFOx) or sham surgery (Sham) and then placed on a high-salt (2% NaCl) diet. One week later, rats were instrumented for radiotelemetric measurement of mean arterial pressure (MAP) and heart rate (HR) and placed in metabolic cages to measure sodium and water balance. Baseline MAP was slightly (but not statistically) lower in SFOx compared with Sham rats during the 5 day control period. During the subsequent 10 days of Ang II administration, MAP was statistically lower in SFOx rats. However, when MAP responses to Ang II were analysed by comparing the change from the 5 day baseline period, only on the fifth day of Ang II was MAP significantly different between groups. There were no differences between groups for water or sodium balance throughout the protocol. We conclude that, although the SFO is required for the complete expression of Ang II-salt hypertension in the rat, other brain sites are also involved.
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