ArticlePharmacology, biochemistry, and behavior2012
A role for 5-HT1A receptors in the basolateral amygdala in the development of conditioned defeat in Syrian hamsters.
Article in Pharmacology, biochemistry, and behavior, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 27 citations in OpenAlex.
- Lateralization of the 5-HTAmino acids · 2024Article
- StandardizedAntioxidants (Basel, Switzerland) · 2020Article
- Assessment of fear and anxiety associated behaviors, physiology and neural circuits in rats with reduced serotonin transporter (SERT) levels.Translational psychiatry · 2019Article
- LRRK2 G2019S Induces Anxiety/Depression-like Behavior before the Onset of Motor Dysfunction with 5-HTThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Serotonin Mediates Depression of Aggression After Acute and Chronic Social Defeat Stress in a Model Insect.Frontiers in behavioral neuroscience · 2018Article
- Dominance status alters restraint-induced neural activity in brain regions controlling stress vulnerability.Physiology & behavior · 2017Article
- Input-specific contributions to valence processing in the amygdala.Learning & memory (Cold Spring Harbor, N.Y.) · 2016Review
- Neurochemical correlates of accumbal dopamine D2 and amygdaloid 5-HT 1B receptor densities on observational learning of aggression.Cognitive, affective & behavioral neuroscience · 2015Article
- Activation of 5-HT2a receptors in the basolateral amygdala promotes defeat-induced anxiety and the acquisition of conditioned defeat in Syrian hamsters.Neuropharmacology · 2015Article
- Article
- 5-HT1A receptor activation reduces fear-related behavior following social defeat in Syrian hamsters.Pharmacology, biochemistry, and behavior · 2014Article
- Serotonergic innervation of the amygdala: targets, receptors, and implications for stress and anxiety.Histochemistry and cell biology · 2013Review
- Defeat-induced activation of the ventral medial prefrontal cortex is necessary for resistance to conditioned defeat.Behavioural brain research · 2013Article
- Serotonergic innervation and serotonin receptor expression of NPY-producing neurons in the rat lateral and basolateral amygdaloid nuclei.Brain structure & function · 2013Article
- A double dissociation in the effects of 5-HT2A and 5-HT2C receptors on the acquisition and expression of conditioned defeat in Syrian hamsters.Behavioral neuroscience · 2012Article
- Social status alters defeat-induced neural activation in Syrian hamsters.Neuroscience · 2012Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The basolateral nucleus of the amygdala (BLA) is a key brain region regulating behavioral changes following stressful events, including social defeat. Previous research has shown that activation of serotonin (5-HT) 1A receptors in the BLA reduces conditioned fear and anxiety-like behavior. The objective of this study was to test whether 5-HT1A receptors in the BLA contribute to conditioned defeat in male Syrian hamsters (Mesocricetus auratus). We tested whether injection of the selective 5-HT1A receptor agonist flesinoxan (400 ng, 800 ng, or 1200 ng in 200 nl saline) into the BLA prior to social defeat would reduce the acquisition of conditioned defeat, and whether a similar injection prior to testing would reduce the expression of conditioned defeat. We also tested whether injection of the selective 5-HT1A receptor antagonist WAY-100635 (400 ng or 1600 ng in 200 nl saline) into the BLA prior to social defeat would enhance the acquisition of conditioned defeat, and whether a similar injection prior to testing would enhance the expression of conditioned defeat. We found that injection of flesinoxan into the BLA decreased both the acquisition and expression of conditioned defeat. However, injection of WAY-100635 into the BLA did not alter the acquisition or expression of conditioned defeat. These data indicate that pharmacological activation of 5-HT1A receptors in the BLA is sufficient to impair the acquisition and expression of conditioned defeat. Our results suggest that pharmacological treatments that activate 5-HT1A receptors in the BLA are capable of reducing the development of stress-induced changes in behavior.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.