ArticleBiological psychology2012
Cortisol responses to emotional stress in men: association with a functional polymorphism in the 5HTR2C gene.
Article in Biological psychology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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Who cites it
27 citing papers in PubMed, 50 citations in OpenAlex.
- Peripheral blood gene expression signatures which reflect smoking and aspirin exposure are associated with cardiovascular events.BMC medical genomics · 2018Trial
- Clinical study of electro-acupuncture treatment with different intensities for functional constipation patients.Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban · 2014Trial
- Examining hypothalamic-pituitary-adrenal axis genetic variation on cortisol and alpha-amylase reactivity during an explicit negative-evaluative stress induction.Stress and health : journal of the International Society for the Investigation of Stress · 2024Article
- Comprehensive Review of Chronic Stress Pathways and the Efficacy of Behavioral Stress Reduction Programs (BSRPs) in Managing Diseases.International journal of environmental research and public health · 2024Review
- Emphasizing the Crosstalk Between Inflammatory and Neural Signaling in Post-traumatic Stress Disorder (PTSD).Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2023Review
- The Role of Sex in Genetic Association Studies of Depression.Journal of psychiatry and brain science · 2022Article
- Monoaminergic Multilocus Genetic Variants Interact with Stressful Life Events in Predicting Changes in Adolescent Anxiety Symptoms: A One-year Longitudinal Study.Journal of youth and adolescence · 2021Article
- Longitudinal Change in Cortisol Levels Across the Adult Life Span.The journals of gerontology. Series A, Biological sciences and medical sciences · 2020Article
- Association between serotonin 2C receptor gene (HTR2C) polymorphisms and psychopathological symptoms in children and adolescents.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2018Article
- Brain-derived neurotrophic factor (BDNF) Val66Met polymorphism interacts with gender to influence cortisol responses to mental stress.Psychoneuroendocrinology · 2017Article
- The genetics of anxiety-related negative valence system traits.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2017Review
- The Trier Social Stress Test: Principles and practice.Neurobiology of stress · 2017Review
- Nonsynonymous HTR2C polymorphism predicts cortisol response to psychosocial stress I: Effects in males and females.Psychoneuroendocrinology · 2016Article
- Additive genetic risk from five serotonin system polymorphisms interacts with interpersonal stress to predict depression.Journal of abnormal psychology · 2015Article
- Influence of Altered Hormonal Status on Platelet 5-HT and MAO-B Activity in Cigarette Smokers.Indian journal of clinical biochemistry : IJCB · 2015Article
- Associations between central nervous system serotonin, fasting glucose, and hostility in African American females.Annals of behavioral medicine : a publication of the Society of Behavioral Medicine · 2015Article
- Identification of Spinal Cord MicroRNA and Gene Signatures in a Model of Chronic Stress-Induced Visceral Hyperalgesia in Rat.PloS one · 2015Article
- A functional polymorphism in the HTR2C gene associated with stress responses: a validation study.Biological psychology · 2014Article
- Variation within the serotonin (5-HT) 5-HT₂C receptor system aligns with vulnerability to cocaine cue reactivity.Translational psychiatry · 2014Article
- Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
The serotonin 5HTR2C receptor has been shown to mediate HPA axis activation during stress. We hypothesized that a functional polymorphism (rs6318) of the 5HTR2C gene would be associated with HPA axis response to a laboratory stress protocol. The present sample consisted of 41 men (22 African Americans, 19 Caucasians). We found that at rest men with the more active rs6318 Ser23 C allele had similar cortisol values compared to those with the less active Cys23 G allele. During laboratory stress, however, men with the Ser23 C allele exhibited the predicted significantly higher cortisol levels (p<0.001), as well as larger increases in anger (p=0.08) and depressive mood (p=0.006) ratings, compared to the Cys23 G carriers. The increase in cortisol was significantly related to the increases in ratings of anger and depression assessed before and after the emotion induction, and these correlations became nonsignificant when rs6318 genotype was covaried. We conclude that genetic variation in 5HTR2C may be associated with HPA axis activation and stimulated by emotional stress, and also with both psychological and physiological endophenotypes that increase the risk of cardiovascular disease and type-2 diabetes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.