ArticleThe American journal of pathology2011
Diesel exhaust particulates exacerbate asthma-like inflammation by increasing CXC chemokines.
Article in The American journal of pathology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 45 citations in OpenAlex.
- Inflammatory Dysregulation, Asthma, and Obesity in Children: What is the Relationship?Journal of inflammation research · 2026Review
- Pollutant particle priming amplifies airway compartment specific neutrophil and macrophage inflammatory programs following house dust mite acute exposure.Frontiers in immunology · 2026Article
- Anti-IL-5 treatment, but not neutrophil interference, attenuates inflammation in a mixed granulocytic asthma mouse model, elicited by air pollution.Respiratory research · 2025Article
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- Structural Racism and the Social Determinants of Health in Asthma.Advances in experimental medicine and biology · 2023Article
- Contribution of systemic and airway immune responses to pediatric obesity-related asthma.Paediatric respiratory reviews · 2021Review
- Boysenberry and apple juice concentrate reduced acute lung inflammation and increased M2 macrophage-associated cytokines in an acute mouse model of allergic airways disease.Food science & nutrition · 2021Article
- The Role and Potential Pathogenic Mechanism of Particulate Matter in Childhood Asthma: A Review and Perspective.Journal of immunology research · 2020Review
- Modeling the Effect of the Aryl Hydrocarbon Receptor on Transplant Immunity.Transplantation direct · 2017Article
- Comment on "Long-Term Effects of Diesel Exhaust Particles on Airway Inflammation and Remodeling in a Mouse Model" by Kim et al.Allergy, asthma & immunology research · 2017Article
- Effects of diesel exhaust particle exposure on a murine model of asthma due to soybean.PloS one · 2017Article
- Long-Term Effects of Diesel Exhaust Particles on Airway Inflammation and Remodeling in a Mouse Model.Allergy, asthma & immunology research · 2016Article
- Impact of acute exposure to WTC dust on ciliated and goblet cells in lungs of rats.Inhalation toxicology · 2015Article
- Ambient particulate matter induces an exacerbation of airway inflammation in experimental asthma: role of interleukin-33.Clinical and experimental immunology · 2014Article
- A mouse model links asthma susceptibility to prenatal exposure to diesel exhaust.The Journal of allergy and clinical immunology · 2014Article
- Diesel exhaust particle exposure increases severity of allergic asthma in young mice.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2013Article
- Chemokines mediate ethanol-induced exacerbations of murine cockroach allergen asthma.Clinical and experimental immunology · 2013Article
- Pulmonary effects of diesel exhaust: neutrophilic inflammation, oxidative injury, and asthma.The American journal of pathology · 2011Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Particulate matter heavily pollutes the urban atmosphere, and several studies show a link between increased ambient particulate air pollution and exacerbation of pre-existing pulmonary diseases, including asthma. We investigated how diesel exhaust particulates (DEPs) aggravate asthma-like pulmonary inflammation in a mouse model of asthma induced by a house dust extract (HDE) containing cockroach allergens and endotoxin. BALB/c mice were exposed to three pulmonary challenges via hypopharyngeal administration of an HDE collected from the home of an asthmatic child. One hour before each pulmonary challenge, mice were exposed to DEP or PBS. Pulmonary inflammation was assessed by histological features, oxidative stress, respiratory physiological features, inflammatory cell recruitment, and local CXC chemokine production. To prove the role of CXC chemokines in the augmented inflammation, CXC chemokine-specific antibodies were delivered to the lungs before DEP exposure. DEP exacerbated HDE-induced airway inflammation, with increased airway mucus production, oxidative stress, inflammatory cell infiltration, bronchoalveolar lavage concentrations of CXC chemokines, and airway hyperreactivity. Neutralization of airway keratinocyte-derived chemokine and macrophage inflammatory protein-2 significantly improves the respiratory function in addition to decreasing the infiltration of neutrophils and eosinophils. Blocking the chemokines also decreased airway mucus production. These results demonstrate that DEP exacerbates airway inflammation induced by allergen through increased pulmonary expression of the CXC chemokines (keratinocyte-derived chemokine and macrophage inflammatory protein-2).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.