ArticleAnalytical chemistry2011
Analysis of native biological surfaces using a 100 kV massive gold cluster source.
Article in Analytical chemistry, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Dysregulation of cellular membrane homeostasis as a crucial modulator of cancer risk.The FEBS journal · 2024Review
- Advancements in ToF-SIMS imaging for life sciences.Frontiers in chemistry · 2023Review
- Therapeutic Effects of Myriocin in Experimental Alcohol-Related Neurobehavioral Dysfunction and Frontal Lobe White Matter Biochemical Pathology.Journal of behavioral and brain science · 2022Article
- Submicron 3-D mass spectrometry imaging reveals an asymmetric molecular distribution on chemotaxing cells.F1000Research · 2022Article
- Three Dimensional Secondary Ion Mass Spectrometry Imaging (3D-SIMS) ofJournal of analytical atomic spectrometry · 2019Article
- Functional link between plasma membrane spatiotemporal dynamics, cancer biology, and dietary membrane-altering agents.Cancer metastasis reviews · 2018Review
- Imaging mass spectrometry of frontal white matter lipid changes in human alcoholics.Alcohol (Fayetteville, N.Y.) · 2018Article
- Altered temporal lobe white matter lipid ion profiles in an experimental model of sporadic Alzheimer's disease.Molecular and cellular neurosciences · 2017Article
- Analysis of Chemotherapeutic Drug Delivery at the Single Cell Level Using 3D-MSI-TOF-SIMS.Journal of the American Society for Mass Spectrometry · 2016Article
- Lipid specific molecular ion emission as a function of the primary ion characteristics in TOF-SIMS.Journal of vacuum science and technology. B, Nanotechnology & microelectronics : materials, processing, measurement, & phenomena : JVST B · 2016Article
- Changes in lipid distribution in E. coli strains in response to norfloxacin.Journal of mass spectrometry : JMS · 2015Article
- Secondary ion mass spectrometry imaging of Dictyostelium discoideum aggregation streams.PloS one · 2014Article
- Surface characterization of biological nanodomains using NP-ToF-SIMS.Surface and interface analysis : SIA · 2013Article
- Simultaneous detection and localization of secondary ions and electrons from single large cluster impacts.Surface and interface analysis : SIA · 2013Article
- Mass spectrometry imaging and profiling of single cells.Journal of proteomics · 2012Review
- Mapping of phospholipids by MALDI imaging (MALDI-MSI): realities and expectations.Chemistry and physics of lipids · 2012Review
- On the Surface Mapping using Individual Cluster Impacts.Nuclear instruments & methods in physics research. Section B, Beam interactions with materials and atoms · 2012Article
- Analysis of Fluorescent Proteins with a Nanoparticle Probe.The journal of physical chemistry letters · 2012Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
In the present work, the advantages of a new, 100 kV platform equipped with a massive gold cluster source for the analysis of native biological surfaces are shown. Inspection of the molecular ion emission as a function of projectile size demonstrates a secondary ion yield increase of ~100× for 520 keV Au(400)(4+) as compared to 130 keV Au(3)(1+) and 43 keV C(60). In particular, yields of tens of percent of molecular ions per projectile impact for the most abundant components can be observed with the 520 keV Au(400)(4+) probe. A comparison between 520 keV Au(400)(4+) time-of-flight-secondary ion mass spectrometry (TOF-SIMS) and matrix assisted laser desorption ionization-mass spectrometry (MALDI-MS) data showed a similar pattern and similar relative intensities of lipid components across a rat brain sagittal section. The abundant secondary ion yield of analyte-specific ions makes 520 keV Au(400)(4+) projectiles an attractive probe for submicrometer molecular mapping of native surfaces.
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