Evidence map›Paper›PMID 21967244›Full record

ArticleNano letters2011

Reactive oxygen species driven angiogenesis by inorganic nanorods.

Chitta Ranjan Patra, Jong-Ho Kim, Kallal Pramanik, Livius V d'Uscio, Sujata Patra, Krishnendu Pal, Ramani Ramchandran, Michael S Strano, Debabrata Mukhopadhyay

Abstract read
In one paragraph

Article in Nano letters, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  15. Zebrafish: an in vivo model for nano EHS studies.Small (Weinheim an der Bergstrasse, Germany) · 2013
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Chitta Ranjan PatraDepartment of Chemical Biology, Indian Institute of Chemical Technology, Uppal Road, Tarnaka, Hyderabad 500607, AP, India. CRPatra@iict.res.in
Jong-Ho Kim
Kallal Pramanik
Livius V d'Uscio
Sujata Patra
Krishnendu Pal
Ramani Ramchandran
Michael S Strano
Debabrata Mukhopadhyay

Funding

Targeting Pancreatic Cancer Using Peptide Chemistry: From Bench to BedsideR01CA150190 · NCI · MAYO CLINIC ROCHESTER · PI MIERKE, DALE F, MUKHOPADHYAY, DEBABRATA · 2010 to 2021
$5.7M
Distinct Pathways of VPF/VEGF ReceptorsR01HL070567 · NHLBI · MAYO CLINIC ROCHESTER · PI MUKHOPADHYAY, DEBABRATA · 2002 to 2014
$4.7M
Roundabout4 signaling in endothelial cellsR01HL090712 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI RAMCHANDRAN, RAMANI · 2009 to 2012
$1.8M
NCI NIH HHS CA150190NCI NIH HHS R01 CA150190NHLBI NIH HHS HL090712NHLBI NIH HHS HL70567NHLBI NIH HHS R01 HL070567NHLBI NIH HHS R01 HL090712
6 · The paper itself

Abstract

The exact mechanism of angiogenesis by europium hydroxide nanorods was unclear. In this study we have showed that formation of reactive oxygen species (H(2)O(2) and O(2)·-) is involved in redox signaling pathways during angiogenesis, important for cardiovascular and ischemic diseases. Here we used single-walled carbon nanotube sensor array to measure the single-molecule efflux of H(2)O(2) and a HPLC method for the determination of O(2)·- from endothelial cells in response to proangiogenic factors. Additionally, reactive oxygen species-mediated angiogenesis using inorganic nanorods was observed in transgenic (fli1a:EGFP) zebrafish embryos.

Indexed as

Cells, CulturedEndothelial CellsHumansInorganic ChemicalsNanoparticlesNeovascularization, PhysiologicReactive Oxygen SpeciesInorganic ChemicalsReactive Oxygen Species

Identifiers

PMID21967244
PMCPMC3212653

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.