ArticleGenes, brain, and behavior2012
Gene networks and haloperidol-induced catalepsy.
Article in Genes, brain, and behavior, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 25 citations in OpenAlex.
- Coexpression of the discoidin domain receptor 1 gene with oligodendrocyte-related and schizophrenia risk genes in the developing and adult human brain.Brain and behavior · 2021Article
- Brain gene co-expression networks link complement signaling with convergent synaptic pathology in schizophrenia.Nature neuroscience · 2021Observational
- Alignment of the transcriptome with individual variation in animals selectively bred for High Drinking-In-the-Dark (HDID).Alcohol (Fayetteville, N.Y.) · 2017Article
- Integrative Analysis of Genetic, Genomic, and Phenotypic Data for Ethanol Behaviors: A Network-Based Pipeline for Identifying Mechanisms and Potential Drug Targets.Methods in molecular biology (Clifton, N.J.) · 2017Article
- NeuN+ neuronal nuclei in non-human primate prefrontal cortex and subcortical white matter after clozapine exposure.Schizophrenia research · 2016Article
- A Systems Approach Implicates a Brain Mitochondrial Oxidative Homeostasis Co-expression Network in Genetic Vulnerability to Alcohol Withdrawal.Frontiers in genetics · 2016Article
- GeneWeaver: finding consilience in heterogeneous cross-species functional genomics data.Mammalian genome : official journal of the International Mammalian Genome Society · 2015Article
- Splicing landscape of the eight collaborative cross founder strains.BMC genomics · 2015Article
- Cosplicing network analysis of mammalian brain RNA-Seq data utilizing WGCNA and Mantel correlations.Frontiers in genetics · 2015Article
- Ethical and public policy challenges for pharmacogenomics.Dialogues in clinical neuroscience · 2014Review
- Dual-trait selection for ethanol consumption and withdrawal: genetic and transcriptional network effects.Alcoholism, clinical and experimental research · 2014Article
- Multi-omic network signatures of disease.Frontiers in genetics · 2014Article
- Correlated mRNAs and miRNAs from co-expression and regulatory networks affect porcine muscle and finally meat properties.BMC genomics · 2013Article
- Selection for drinking in the dark alters brain gene coexpression networks.Alcoholism, clinical and experimental research · 2013Article
- Genes, behavior and next-generation RNA sequencing.Genes, brain, and behavior · 2013Review
- Article
- Utilizing RNA-Seq data for de novo coexpression network inference.Bioinformatics (Oxford, England) · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
The current study examined the changes in striatal gene network structure induced by short-term selective breeding from a heterogeneous stock for haloperidol response. Brain (striatum) gene expression data were obtained using the Illumina WG 8.2 array, and the datasets from responding and non-responding selected lines were independently interrogated using a weighted gene coexpression network analysis (WGCNA). We detected several gene modules (groups of coexpressed genes) in each dataset; the membership of the modules was found to be largely concordant, and a consensus network was constructed. Further validation of the network topology showed that using approximately 35 samples is sufficient to reliably infer the transcriptome network. An in-depth analysis showed significant changes in network structure and gene connectivity associated with the selected lines; these changes were validated using a bootstrapping procedure. The most dramatic changes were associated with a gene module richly annotated with neurobehavioral traits. The changes in network connectivity were concentrated in the links between this module and the rest of the network, in addition to changes within the module; this observation is consistent with recent results in protein and metabolic networks. These results suggest that a network-based strategy will help identify the genetic factors associated with haloperidol response.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.