ArticleBMC genomics2011
Sequence comparison of prefrontal cortical brain transcriptome from a tame and an aggressive silver fox (Vulpes vulpes).
Article in BMC genomics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- Organization of distributed cortical connections underlying the processing of auditory information in dogs assessed by diffusion MRI.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Molecular signature of excessive female aggression: study of stressed mice with genetic inactivation of neuronal serotonin synthesis.Journal of neural transmission (Vienna, Austria : 1996) · 2023Article
- The brain of the silver fox (Vulpes vulpes): a neuroanatomical reference of cell-stained histological and MRI images.Brain structure & function · 2023Article
- Transcriptome analysis provides new insights into cold adaptation of corsac fox (Ecology and evolution · 2022Article
- Age Effects Aggressive Behavior: RNA-Seq Analysis in Cattle with Implications for Studying Neoteny Under Domestication.Behavior genetics · 2022Article
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- Gene expression profiles underlying aggressive behavior in the prefrontal cortex of cattle.BMC genomics · 2021Article
- Ecotype differences in aggression, neural activity and behaviorally relevant gene expression in cichlid fish.Genes, brain, and behavior · 2020Article
- How research on female vertebrates contributes to an expanded challenge hypothesis.Hormones and behavior · 2020Review
- The Australian dingo: untamed or feral?Frontiers in zoology · 2019Article
- Epigenetics and early domestication: differences in hypothalamic DNA methylation between red junglefowl divergently selected for high or low fear of humans.Genetics, selection, evolution : GSE · 2018Article
- DNA methylation patterns of behavior-related gene promoter regions dissect the gray wolf from domestic dog breeds.Molecular genetics and genomics : MGG · 2017Article
- The concerted impact of domestication and transposon insertions on methylation patterns between dogs and grey wolves.Molecular ecology · 2016Article
- Natural variation in brain gene expression profiles of aggressive and nonaggressive individual sticklebacks.Behaviour · 2016Article
- Genetic signatures of adaptation revealed from transcriptome sequencing of Arctic and red foxes.BMC genomics · 2015Article
- Transcriptome Analysis in Domesticated Species: Challenges and Strategies.Bioinformatics and biology insights · 2015Review
- Genotyping-By-Sequencing (GBS) Detects Genetic Structure and Confirms Behavioral QTL in Tame and Aggressive Foxes (Vulpes vulpes).PloS one · 2015Article
- Microsatellite polymorphism and its association with body weight and selected morphometrics of farm red fox (Vulpes vulpes L.).Journal of applied genetics · 2014Article
- Analysis of the canine brain transcriptome with an emphasis on the hypothalamus and cerebral cortex.Mammalian genome : official journal of the International Mammalian Genome Society · 2013Article
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Authors and funding
17 authors.
Funding
Abstract
backgroundTwo strains of the silver fox (Vulpes vulpes), with markedly different behavioral phenotypes, have been developed by long-term selection for behavior. Foxes from the tame strain exhibit friendly behavior towards humans, paralleling the sociability of canine puppies, whereas foxes from the aggressive strain are defensive and exhibit aggression to humans. To understand the genetic differences underlying these behavioral phenotypes fox-specific genomic resources are needed.
resultscDNA from mRNA from pre-frontal cortex of a tame and an aggressive fox was sequenced using the Roche 454 FLX Titanium platform (> 2.5 million reads & 0.9 Gbase of tame fox sequence; >3.3 million reads & 1.2 Gbase of aggressive fox sequence). Over 80% of the fox reads were assembled into contigs. Mapping fox reads against the fox transcriptome assembly and the dog genome identified over 30,000 high confidence fox-specific SNPs. Fox transcripts for approximately 14,000 genes were identified using SwissProt and the dog RefSeq databases. An at least 2-fold expression difference between the two samples (p < 0.05) was observed for 335 genes, fewer than 3% of the total number of genes identified in the fox transcriptome.
conclusionsTranscriptome sequencing significantly expanded genomic resources available for the fox, a species without a sequenced genome. In a very cost efficient manner this yielded a large number of fox-specific SNP markers for genetic studies and provided significant insights into the gene expression profile of the fox pre-frontal cortex; expression differences between the two fox samples; and a catalogue of potentially important gene-specific sequence variants. This result demonstrates the utility of this approach for developing genomic resources in species with limited genomic information.
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