ArticleClinical science (London, England : 1979)2012
STIM1/Orai1 contributes to sex differences in vascular responses to calcium in spontaneously hypertensive rats.
Article in Clinical science (London, England : 1979), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 28 citations in OpenAlex.
- The nonexcitable smooth muscle: remodeling the smooth muscle ion transport toolkit in disease.Physiological reviews · 2026Review
- Vascular mechanotransduction.Physiological reviews · 2023Review
- Connecting Aortic Stiffness to Vascular Contraction: Does Sex Matter?International journal of molecular sciences · 2022Article
- Role of store-operated Ca2+ entry in cardiovascular disease.Cell communication and signaling : CCS · 2022Review
- Relevance of stromal interaction molecule 1 (STIM1) in experimental and human stroke.Pflugers Archiv : European journal of physiology · 2022Review
- Impaired HSP70 Expression in the Aorta of Female Rats: A Novel Insight Into Sex-Specific Differences in Vascular Function.Frontiers in physiology · 2021Article
- ORAI channels in cellular remodeling of cardiorespiratory disease.Cell calcium · 2019Review
- Stroke and the neurovascular unit: glial cells, sex differences, and hypertension.American journal of physiology. Cell physiology · 2019Article
- The deregulation of STIM1 and store operative calcium entry impaired aortic smooth muscle cells contractility in aortic medial degeneration.Bioscience reports · 2019Article
- Vascular smooth muscle contraction in hypertension.Cardiovascular research · 2018Review
- Essential Role of Smooth Muscle STIM1 in Hypertension and Cardiovascular Dysfunction.Arteriosclerosis, thrombosis, and vascular biology · 2016Article
- Sex-specific alterations in NOS regulation of vascular function in aorta and mesenteric arteries from spontaneously hypertensive rats compared to Wistar Kyoto rats.Physiological reports · 2014Article
- Symphony of vascular contraction: how smooth muscle cells lose harmony to signal increased vascular resistance in hypertension.Hypertension (Dallas, Tex. : 1979) · 2014Review
- Emerging roles of Orai3 in pathophysiology.Channels (Austin, Tex.)Review
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
Sex differences in Ca2+-dependent signalling and homoeostasis in the vasculature of hypertensive rats are well characterized. However, sex-related differences in SOCE (store-operated Ca2+ entry) have been minimally investigated. We hypothesized that vascular protection in females, compared with males, reflects decreased Ca2+ mobilization due to diminished activation of Orai1/STIM1 (stromal interaction molecule 1). In addition, we investigated whether ovariectomy in females affects the activation of the Orai1/STIM1 pathway. Endothelium-denuded aortic rings from male and female SHRSP (stroke-prone spontaneously hypertensive rats) and WKY (Wistar-Kyoto) rats and from OVX (ovariectomized) or sham female SHRSP and WKY rats were used to functionally evaluate Ca2+ influx-induced contractions. Compared with females, aorta from male SHRSP displayed: (i) increased contraction during the Ca2+-loading period; (ii) similar transient contraction during Ca2+ release from the intracellular stores; (iii) increased activation of STIM1 and Orai1, as shown by the blockade of STIM1 and Orai1 with neutralizing antibodies, which reversed the sex differences in contraction during the Ca2+-loading period; and (iv) increased expression of STIM1 and Orai1. Additionally, we found that aortas from OVX-SHRSP showed increased contraction during the Ca2+-loading period and increased Orai1 expression, but no changes in the SR (sarcoplasmic reticulum)-buffering capacity or STIM1 expression. These findings suggest that augmented activation of STIM1/Orai1 in aortas from male SHRSP represents a mechanism that contributes to sex-related impaired control of intracellular Ca2+ levels. Furthermore, female sex hormones may negatively modulate the STIM/Orai1 pathway, contributing to vascular protection observed in female rats.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.