ArticleJournal of cachexia, sarcopenia and muscle2011
Increased desmin expression in hindlimb muscles of aging rats.
Article in Journal of cachexia, sarcopenia and muscle, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed.
- The nucleus as a mechanobiological hub in muscle aging.Nucleus (Austin, Tex.) · 2026Review
- In situ spatial transcriptomic analysis of human skeletal muscle using the Xenium platform.Cell and tissue research · 2025Article
- Across the space: applications of spatial transcriptomic technology in healthy and diseased muscle.Frontiers in cell and developmental biology · 2025Review
- AAV9-mediated SMN gene therapy rescues cardiac desmin but not lamin A/C and elastin dysregulation in Smn2B/- spinal muscular atrophy mice.Human molecular genetics · 2023Article
- Proteomic analysis reveals that aging rabbit vocal folds are more vulnerable to changes caused by systemic dehydration.BMC genomics · 2022Article
- What does desmin do: A bibliometric assessment of the functions of the muscle intermediate filament.Experimental biology and medicine (Maywood, N.J.) · 2022Article
- Review
- Wheel running predicts resilience to tumors in old mice.Pathobiology of aging & age related diseases · 2019Article
- Iron limitation promotes the atrophy of skeletal myocytes, whereas iron supplementation prevents this process in the hypoxic conditions.International journal of molecular medicine · 2018Article
- Synemin: an evolving role in tumor growth and progression.Journal of cachexia, sarcopenia and muscle · 2014Article
- Highlights of mechanistic and therapeutic cachexia and sarcopenia research 2010 to 2012 and their relevance for cardiology.Archives of medical science : AMS · 2013Review
- Evolving concepts on the age-related changes in "muscle quality".Journal of cachexia, sarcopenia and muscle · 2012Article
- What is dynapenia?Nutrition (Burbank, Los Angeles County, Calif.) · 2012Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAging skeletal muscle frequently exhibits a reduction in force produced per unit muscle tissue, variously termed muscle quality, specific tension or dynapenia. Muscles from animals in which desmin expression is reduced exhibit similar properties, raising the possibility that reduced desmin expression contributes to impaired force production in aging muscles.
methodsWe examined expression of desmin and synemin, both intermediate filament proteins, in the plantarflexor muscles of adult (6-8 months) and older (24 months) rats. We have previously reported age-related reductions in muscle quality and sarcoplasmic reticulum function in these animals.
resultsSignificant effects of age and muscle were found for the expression of desmin (P = 0.040 and <0.001 respectively), but not synemin. Desmin expression was increased in the aging muscles, with the greatest changes observed in the gastrocnemius muscles. Muscle quality, but not muscle mass, was reduced in the aging plantarflexor muscles.
conclusionsLoss of desmin does not account for reduced force production in aging muscles. The potential effects of the age-related increase in desmin on muscle function remain unclear, but may include dissipation of contractile force.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.