ArticleCommunicative & integrative biology2011
Video imaging of the sperm acrosome reaction during in vitro fertilization.
Article in Communicative & integrative biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
9 citing papers in PubMed.
- Extraction, purification, biological effects and applications of acrosin: a review.Frontiers in cellular and infection microbiology · 2025Review
- Diversity of sialic acids and sialoglycoproteins in gametes and at fertilization.Frontiers in cell and developmental biology · 2022Review
- Functional amyloids of eukaryotes: criteria, classification, and biological significance.Current genetics · 2020Review
- The Acrosomal Matrix.Advances in anatomy, embryology, and cell biology · 2016Review
- Redistribution of the intra-acrosomal EGFP before acrosomal exocytosis in mouse spermatozoa.Reproduction (Cambridge, England) · 2015Article
- Functional amyloids in the mouse sperm acrosome.Molecular and cellular biology · 2014Article
- Heads or tails? Structural events and molecular mechanisms that promote mammalian sperm acrosomal exocytosis and motility.Molecular reproduction and development · 2012Review
- Transitional states of acrosomal exocytosis and proteolytic processing of the acrosomal matrix in guinea pig sperm.Molecular reproduction and development · 2011Article
- Bactericidal/permeability-increasing protein originates in both the testis and the epididymis and localizes in mouse spermatozoa.Asian journal of andrologyArticle
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mammalian spermatozoa become competent for fusion with oocytes while traveling through the female reproductive tract and the oocyte's extracellular investments. Recent studies highlighted the molecular mechanism of the sperm's interactions with the zona pellucida (ZP), the extracellular coat surrounding the oocyte. Fertilizing spermatozoa initiate the sperm acrosome reaction (AR), essential for zona penetration and fusion with the oocyte plasma membrane, before they reach the ZP. However, the exact condition of spermatozoa that leads to successful penetration of the ZP remains unknown. We performed microscopic observations of in vitro fertilization with genetically (EGFP) and chemically (antibody and lectin) labeled spermatozoa to monitor the progression of the AR. Spermatozoa exhibiting EGFP(-)/PNA(+) prior to binding to the ZP initiated zona penetration. This result suggests that spermatozoa that have undergone the AR are still capable of binding and penetrating the ZP.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.