ArticleCommunicative & integrative biology2011
Sleep homeostasis: Progress at a snail's pace.
Article in Communicative & integrative biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- Article
- Unraveling the complexities of circadian and sleep interactions with memory formation through invertebrate research.Frontiers in systems neuroscience · 2014Review
- A simple model for the origin of quasiperiodic ultradian rhythms in sleep-wake state in the rat.Communicative & integrative biology · 2013Article
Corrections and comments
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Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We recently reported that a gastropod mollusc, Lymnaea stagnalis, exhibits a sleep-like quiescent state. However quiescence differed from mammalian sleep in that both circadian and homeostatic regulation seemed to be absent in the snail. In the present paper I explore the possibility that the clustered pattern of quiescence observed in the snail may provide insight into underlying regulatory mechanisms. Specifically, I hypothesize that clustering of quiescence arises from feedback modulation of a stochastic wake-quiescence oscillator. The feedback loop is postulated to limit cumulative wakefulness and to exert probabilistic modulation of wake duration. Computer simulations using this model succeeded in simulating snail wake-quiescence behavior, confirming the plausibility of the hypothesis. Implications of this analysis for our understanding of mechanisms and evolution of sleep homeostasis are discussed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.