ArticlePloS one2011
Small molecule inhibitors of the Candida albicans budded-to-hyphal transition act through multiple signaling pathways.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 42 citations in OpenAlex.
- Promising immunotherapeutic targets for treating candidiasis.Frontiers in cellular and infection microbiology · 2024Review
- Fungal Forces in Mental Health: Microbial Meddlers or Function Fixers?Current topics in behavioral neurosciences · 2023Article
- Antifungal and Anti-Virulent Activity ofMolecules (Basel, Switzerland) · 2022Article
- Hypha essential genes in Candida albicans pathogenesis of oral lichen planus: an in-vitro study.BMC oral health · 2021Article
- pH Changes Have a Profound Effect on Gene Expression, Hydrolytic Enzyme Production, and Dimorphism inFrontiers in microbiology · 2021Article
- Mechanistic Understanding ofFrontiers in microbiology · 2021Review
- Virulence and biofilms as promising targets in developing antipathogenic drugs against candidiasis.Future science OA · 2020Review
- Inhibition of Distinct Proline- orBioMed research international · 2020Article
- Short-Term Probiotic Administration Increases Fecal-AntiMicroorganisms · 2019Article
- Mannich base limits Candida albicans virulence by inactivating Ras-cAMP-PKA pathway.Scientific reports · 2018Article
- Culture Supernatants of Lactobacillus gasseri and L. crispatus Inhibit Candida albicans Biofilm Formation and Adhesion to HeLa Cells.Mycopathologia · 2018Article
- Chemical inhibitors of Candida albicans hyphal morphogenesis target endocytosis.Scientific reports · 2017Article
- Membrane of Candida albicans as a target of berberine.BMC complementary and alternative medicine · 2017Article
- Review
- Alizarin and Chrysazin Inhibit Biofilm and Hyphal Formation byFrontiers in cellular and infection microbiology · 2017Article
- Antifungal Activity of Oleuropein against Candida albicans-The In Vitro Study.Molecules (Basel, Switzerland) · 2016Article
- From Biology to Drug Development: New Approaches to Combat the Threat of Fungal Biofilms.Microbiology spectrum · 2015Article
- Hyphal growth in Candida albicans does not require induction of hyphal-specific gene expression.Molecular biology of the cell · 2015Article
- New strategic insights into managing fungal biofilms.Frontiers in microbiology · 2015Article
- In vitro and in vivo activity of a novel antifungal small molecule against Candida infections.PloS one · 2014Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The ability of the pathogenic yeast Candida albicans to interconvert between budded and hyphal growth states, herein termed the budded-to-hyphal transition (BHT), is important for C. albicans development and virulence. The BHT is under the control of multiple cell signaling pathways that respond to external stimuli, including nutrient availability, high temperature, and pH. Previous studies identified 21 small molecules that could inhibit the C. albicans BHT in response to carbon limitation in Spider media. However, the studies herein show that the BHT inhibitors had varying efficacies in other hyphal-inducing media, reflecting their varying abilities to block signaling pathways associated with the different media. Chemical epistasis analyses suggest that most, but not all, of the BHT inhibitors were acting through either the Efg1 or Cph1 signaling pathways. Notably, the BHT inhibitor clozapine, a FDA-approved drug used to treat atypical schizophrenia by inhibiting G-protein-coupled dopamine receptors in the brain, and several of its functional analogs were shown to act at the level of the Gpr1 G-protein-coupled receptor. These studies are the first step in determining the target and mechanism of action of these BHT inhibitors, which may have therapeutic anti-fungal utility in the future.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.