ArticlePloS one2011
A test of the coordinated expression hypothesis for the origin and maintenance of the GAL cluster in yeast.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 37 citations in OpenAlex.
- DNA supercoiling restricts the transcriptional bursting of neighboring eukaryotic genes.Molecular cell · 2023Article
- Article
- Article
- Altered expression response upon repeated gene repression in single yeast cells.PLoS computational biology · 2022Article
- The evolution of the GALactose utilization pathway in budding yeasts.Trends in genetics : TIG · 2022Review
- Synchronization of stochastic expressions drives the clustering of functionally related genes.Science advances · 2019Article
- The birth, evolution and death of metabolic gene clusters in fungi.Nature reviews. Microbiology · 2018Review
- UDP-Sugar Producing Pyrophosphorylases: Distinct and Essential Enzymes With Overlapping Substrate Specificities, ProvidingFrontiers in plant science · 2018Review
- Genetic Interaction Network as an Important Determinant of Gene Order in Genome Evolution.Molecular biology and evolution · 2017Article
- Ongoing resolution of duplicate gene functions shapes the diversification of a metabolic network.eLife · 2016Article
- Plant metabolic clusters - from genetics to genomics.The New phytologist · 2016Review
- The evolution of fungal metabolic pathways.PLoS genetics · 2014Article
- In-vivo real-time control of protein expression from endogenous and synthetic gene networks.PLoS computational biology · 2014Article
- Physical linkage of metabolic genes in fungi is an adaptation against the accumulation of toxic intermediate compounds.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Impact of chromosomal inversions on the yeast DAL cluster.PloS one · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Metabolic gene clusters--functionally related and physically clustered genes--are a common feature of some eukaryotic genomes. Two hypotheses have been advanced to explain the origin and maintenance of metabolic gene clusters: coordinated gene expression and genetic linkage. Here we test the hypothesis that selection for coordinated gene expression underlies the clustering of GAL genes in the yeast genome. We find that, although clustering coordinates the expression of GAL1 and GAL10, disrupting the GAL cluster does not impair fitness, suggesting that other mechanisms, such as genetic linkage, drive the origin and maintenance metabolic gene clusters.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.