ArticlePloS one2011
Temporal regulation of rapamycin on memory CTL programming by IL-12.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Characterization of Bovine Intraepithelial T Lymphocytes in the Gut.Pathogens (Basel, Switzerland) · 2023Article
- A novel CD4+ CTL subtype characterized by chemotaxis and inflammation is involved in the pathogenesis of Graves' orbitopathy.Cellular & molecular immunology · 2021Article
- Rapamycin Improves the Response of Effector and Memory CD8Frontiers in cellular and infection microbiology · 2021Article
- Characterization of IL-10-producing neutrophils in cattle infected with Ostertagia ostertagi.Scientific reports · 2019Article
- IL-12 stimulates CTLs to secrete exosomes capable of activating bystander CD8Scientific reports · 2017Article
- Low-dose controlled release of mTOR inhibitors maintains T cell plasticity and promotes central memory T cells.Journal of controlled release : official journal of the Controlled Release Society · 2017Article
- Facile assembly and loading of theranostic polymersomes via multi-impingement flash nanoprecipitation.Journal of controlled release : official journal of the Controlled Release Society · 2017Article
- Effector functions of memory CTLs can be affected by signals received during reactivation.Immunologic research · 2017Article
- Transcriptome profiling of CTLs regulated by rapamycin using RNA-Seq.Immunogenetics · 2014Article
- IL-12 is required for mTOR regulation of memory CTLs during viral infection.Genes and immunity · 2014Article
- Wnt signaling inhibits CTL memory programming.Molecular immunology · 2013Article
- 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) regulates CTL activation and memory programming.Biochemical and biophysical research communications · 2013Article
- Nicotine inhibits memory CTL programming.PloS one · 2013Article
- TLR agonists are highly effective at eliciting functional memory CTLs of effector memory phenotype in peptide immunization.International immunopharmacology · 2013Article
- Repetitive peptide boosting progressively enhances functional memory CTLs.Biochemical and biophysical research communications · 2012Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mammalian target of rapamycin (mTOR) is a master regulator of cell growth. Recent reports have defined its important role in memory cytotoxic T lymphocyte (CTL) differentiation in infections and memory programming. We report that rapamycin regulated memory CTL programming by IL-12 to a similar level in a wide range of concentrations, and the enhanced memory CTLs by rapamycin were functional and provided similar protection against Listeria Monocytogenes challenge compared to the control. In addition, rapamycin-experienced CTLs went through substantially enhanced proliferation after transfer into recipients. Furthermore, the regulatory function of rapamycin on CD62L expression in memory CTLs was mainly contributed by the presence of rapamycin in the first 24-hr of stimulation in vitro, whereas the effective window of rapamycin on the size of memory CTLs was determined between 24 to 72 hrs. In conclusion, rapamycin regulates IL-12-driven programming of CTLs to a similar level in a wide range of concentrations, and regulates the phenotype and the size of memory CTLs in different temporal windows.
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